Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 11/20 | 0.74 |
| ▸ | EYA3 | Q99504 | 4/20 | 0.57 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TNKS | O95271 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7499937 | 0.85 | PTPN1 (1.00) | PTPN1EYA3SLC22A12CYP2C9MAPT | |
| SCHEMBL7497194 | 0.82 | PTPN1 (1.00) | PTPN1 | |
| SCHEMBL7850985 | 0.81 | PTPN1 (0.64) | PTPN1EYA3SLC22A12MAPTSMN1; SMN2 | |
| SCHEMBL29406889 | 0.80 | CYP2C9 (0.55) | PTPN1CYP2C9MAPTSMN1; SMN2MEN1 | |
| SCHEMBL3868415 | 0.80 | PTPN1 (0.97) | PTPN1 | |
| SCHEMBL28104532 | 0.78 | CYP2C19 (0.62) | PTPN1EYA3SLC22A12CYP2C9MAPT | |
| SCHEMBL11471945 | 0.77 | PTPN1 (0.56) | PTPN1EYA3CYP2C9MAPTSMN1; SMN2 | |
| SCHEMBL28294570 | 0.76 | TTR (0.48) | PTPN1EYA3SLC22A12CYP2C9MAPT | |
| SCHEMBL7503917 | 0.76 | PTPN1 (0.57) | PTPN1EYA3SMN1; SMN2MEN1KMT2A | |
| SCHEMBL11750759 | 0.74 | EYA3 (0.55) | PTPN1EYA3SLC22A12CYP2C9MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077967-B1 | BIPHENYL OXO-ACETIC ACIDS USEFUL IN THE TREATMENT OF INSULIN RESISTANCE AND HYPERGLYCEMIA | WYETH CORP (US) | 2002-12-04 | — | — | EP | disclosed |
| US-6391897-B2 | (4'-BENZOFURAN-3-YL-BIPHENYL-4-YLOXY)-ACETIC ACID, FOR EXAMPLE; INHIBIT PROTEIN-TYROSINE PHOSPHATASES (PTPASES) | AMERICAN HOME PRODUCTS CORPORATION | 2002-05-21 | — | — | US | disclosed |
| US-6369072-B2 | Biphenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia | AMERICAN HOME PRODUCTS CORPORATION | 2002-04-09 | — | — | US | disclosed |
| US-20010053785-A1 | Biphenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia | WYETH | 2001-12-20 | — | — | US | disclosed |
| US-20010041715-A1 | Biphenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia | AMERICAN HOME PRODUCTS | 2001-11-15 | — | — | US | disclosed |
| US-6232322-B1 | SUCH AS (4'-BENZOFURAN-3-YL-BIPHENYL-4-YLOXY)-ACETIC ACID OR SALT | AMERICAN HOME PRODUCTS CORPORATION | 2001-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010053785-A1 | Biphenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia | GPR119, INSR, IAPP | PTPN1 1004/4885EYA3 1269/4885SLC22A12 1322/4885 |
| US-20010041715-A1 | Biphenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia | GPR119, INSR, IAPP | PTPN1 1004/4885EYA3 1269/4885SLC22A12 1322/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.