Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | KIF11 | P52732 | 4/20 | 0.43 |
| ▸ | NQO2 | P16083 | 1/20 | 0.40 |
| ▸ | PARP14 | Q460N5 | 9/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | HTR5A | P47898 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2187375 | 0.79 | KMT2A (0.42) | NPC1TP53POLBCASP1RAB9A | |
| SCHEMBL5009823 | 0.78 | BCHE (0.46) | BCHEKIF11NQO2PARP14HTR2B | |
| SCHEMBL31043048 | 0.76 | BCHE (0.49) | BCHEKIF11NQO2PARP14HTR2B | |
| SCHEMBL980073 | 0.74 | BCHE (0.55) | BCHEKIF11PARP14HTR2BHTR5A | |
| SCHEMBL27833818 | 0.74 | PDGFRB (0.60) | BCHEKIF11HTR2BHTR5ATDO2 | |
| SCHEMBL4722008 | 0.74 | ALDH1A1 (0.39) | NQO2NPC1TP53POLBCASP1 | |
| SCHEMBL14337505 | 0.73 | AR (0.54) | BCHEKIF11NQO2PARP14HTR2B | |
| SCHEMBL29733506 | 0.72 | KIF11 (0.63) | BCHEKIF11PARP14GABRPGABRD | |
| SCHEMBL208113 | 0.72 | KIF11 (0.63) | BCHEKIF11PARP14GABRPGABRD | |
| SCHEMBL4328663 | 0.71 | BCHE (0.47) | BCHEKIF11PARP14HTR2BHTR5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8912331-B2 | 3,5-disubstituted-3H-imidazo[4,5-B]pyridine and 3,5-disubstituted-3H-[1,2,3]triazolo[4,5-B] pyridine compounds as modulators of protein kinases | RHIZEN PHARMACEUTICALS SA (CH) | 2014-12-16 | — | — | US | disclosed |
| US-20130261116-A1 | NOVEL 3,5-DISUBSTITUTED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5-DISUBSTITUTED -3H-[1,2,3]TRIAZOLO[4,5-B] PYRIDINE COMPOUNDS AS MODULATORS OF PROTEIN KINASES | RHIZEN PHARMACEUTICALS SA (CH) | 2013-10-03 | — | — | US | disclosed |
| EP-1097155-B1 | PHOTOCHROMIC SIX-MEMBERED HETEROCYCLIC-FUSED NAPHTHOPYRANS | TRANSITIONS OPTICAL INC (US) | 2002-09-18 | — | — | EP | disclosed |
| EP-1097155-A2 | PHOTOCHROMIC SIX-MEMBERED HETEROCYCLIC-FUSED NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 2001-05-09 | — | — | EP | disclosed |
| US-6153126-A | Photochromic six-membered heterocyclilc-fused naphthopyrans | PPG INDUSTRIES OHIO, INC. (US) | 2000-11-28 | — | — | US | disclosed |
| US-6022497-A | NAPHTHOPYRAN COMPOUNDS WHEN EXPOSED TO ELECTROMAGNETIC RADIATION CONTAINING ULTRAVIOLET RAYS, EXHIBIT A REVERSIBLE CHANGE IN COLOR AND WHEN ULTRAVIOLET RADIATION DISCONTINUED THE PHOTOCHROMIC COMPOUND WILL RETURN TO COLORLESS STATE | PPG INDUSTRIES OHIO, INC. (US) | 2000-02-08 | — | — | US | disclosed |
| WO-2000002883-A2 | PHOTOCHROMIC SIX-MEMBERED HETEROCYCLIC-FUSED NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 2000-01-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130261116-A1 | NOVEL 3,5-DISUBSTITUTED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5-DISUBSTITUTED -3H-[1,2,3]TRIAZOLO[4,5-B] PYRIDINE COMPOUNDS AS MODULATORS OF PROTEIN KINASES | MAP4K2, MAP4K3, MAP3K1 | BCHE 3299/4885KIF11 2854/4885NQO2 2667/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.