Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | THRA | P10827 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA3 | P07451 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6810549 | 0.84 | L3MBTL1 (0.57) | L3MBTL1MAPTTSHRHDAC8HDAC1 | |
| SCHEMBL7508166 | 0.83 | ALDH1A1 (0.58) | L3MBTL1MAPTMEN1KMT2ACYP1A2 | |
| SCHEMBL7506850 | 0.83 | NPC1 (0.44) | L3MBTL1MAPTTSHRPDE4BHDAC8 | |
| SCHEMBL6810008 | 0.81 | L3MBTL1 (0.48) | L3MBTL1MAPTTSHRHDAC8HDAC1 | |
| SCHEMBL17094704 | 0.79 | HSD17B3 (0.50) | L3MBTL1MAPTTSHRHDAC8HDAC1 | |
| SCHEMBL7467309 | 0.79 | TSHR (0.52) | L3MBTL1MAPTTSHRPDE4BMEN1 | |
| SCHEMBL3841701 | 0.79 | HDAC1 (0.58) | L3MBTL1MAPTTSHRPDE4BHDAC8 | |
| SCHEMBL3337532 | 0.77 | MAPT (0.46) | L3MBTL1MAPTHDAC8HDAC1MEN1 | |
| SCHEMBL3668982 | 0.77 | HPGD (0.53) | L3MBTL1TSHRHDAC8HDAC1POLB | |
| SCHEMBL9214073 | 0.76 | CA12 (0.54) | L3MBTL1MAPTTSHRPDE4BNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0721942-B1 | TETRACYCLIC COMPOUND | KYOWA HAKKO KOGYO KK (JP) | 2002-06-05 | — | — | EP | disclosed |
| US-5646283-A | IMMUNOSUPPRESSANTS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-07-08 | — | — | US | disclosed |
| EP-0721942-A1 | NOVEL TETRACYCLIC COMPOUND | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1996-07-17 | — | — | EP | disclosed |