Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.48 |
| ▸ | WNT3A | P56704 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | THRA | P10827 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7499557 | 0.83 | L3MBTL1 (0.50) | CYP1A2L3MBTL1MAPTTHRATHRB | |
| SCHEMBL7506850 | 0.83 | NPC1 (0.44) | CYP1A2L3MBTL1MAPTTHRATHRB | |
| SCHEMBL5729109 | 0.82 | ALDH1A1 (0.65) | ALDH1A1CYP1A2CYP2C19CYP2D6HPGD | |
| SCHEMBL8416607 | 0.82 | CTNNB1 (0.47) | ALDH1A1CTNNB1WNT3AKMT2AMEN1 | |
| SCHEMBL31525615 | 0.81 | ALDH1A1 (0.63) | ALDH1A1CYP1A2CYP2C19CYP2D6HPGD | |
| SCHEMBL11790411 | 0.79 | ALDH1A1 (0.65) | ALDH1A1CYP1A2CYP2C19CYP2D6HPGD | |
| SCHEMBL28701105 | 0.79 | ALDH1A1 (0.69) | ALDH1A1CYP1A2CYP2C19CYP2D6HPGD | |
| SCHEMBL29673203 | 0.79 | ALDH1A1 (0.69) | ALDH1A1CYP1A2CYP2C19CYP2D6HPGD | |
| SCHEMBL2775998 | 0.79 | ALDH1A1 (0.69) | ALDH1A1CYP1A2CYP2C19CYP2D6HPGD | |
| SCHEMBL3841701 | 0.79 | HDAC1 (0.58) | ALDH1A1CYP1A2HPGDL3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0721942-B1 | TETRACYCLIC COMPOUND | KYOWA HAKKO KOGYO KK (JP) | 2002-06-05 | — | — | EP | disclosed |
| US-5646283-A | IMMUNOSUPPRESSANTS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-07-08 | — | — | US | disclosed |
| EP-0721942-A1 | NOVEL TETRACYCLIC COMPOUND | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1996-07-17 | — | — | EP | disclosed |