Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA1 | P02708 | 1/20 | 0.55 |
| ▸ | CHRNG | P07510 | 1/20 | 0.55 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.55 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.55 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.55 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.55 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.55 |
| ▸ | CHRND | Q07001 | 1/20 | 0.55 |
| ▸ | CES2 | O00748 | 2/20 | 0.49 |
| ▸ | CES1 | P23141 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7500244 | 0.98 | CHRNA1 (0.54) | CHRNA1CHRNGCHRNB1CHRNB2SLC6A2 | |
| SCHEMBL14691129 | 0.81 | NPC1 (0.44) | CES2CES1SMN1; SMN2GAAMEN1 | |
| SCHEMBL9219903 | 0.81 | CHRNA1 (0.55) | CHRNA1CHRNGCHRNB1CHRNB2SLC6A2 | |
| Hydrochloric Acid SCHEMBL14691126 | 0.80 | NPC1 (0.42) | CES2CES1SMN1; SMN2GAAMEN1 | |
| SCHEMBL3741183 | 0.77 | HPGD (0.48) | CHRNA1CHRNGCHRNB1CHRNB2SLC6A2 | |
| Hydrochloric Acid SCHEMBL3741179 | 0.76 | KMO (0.47) | CHRNA1CHRNGCHRNB1CHRNB2SLC6A2 | |
| SCHEMBL19763136 | 0.75 | CA1 (0.53) | CES2CES1SMN1; SMN2RAB9ALMNA | |
| SCHEMBL14401989 | 0.74 | KMT2A (0.51) | CES2CES1GAAKMT2ALMNA | |
| SCHEMBL5936619 | 0.74 | KMT2A (0.51) | CES2CES1GAAKMT2ALMNA | |
| SCHEMBL8130880 | 0.74 | MAPK8 (0.41) | GAADPP4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140906-A4 | IMIDAZOLONES AND THEIR USE IN TREATING BENIGN PROSTATIC HYPERPLASIA AND OTHER DISORDERS | SYNAPTIC PHARMA CORP (US) | 2002-03-13 | — | — | EP | disclosed |
| EP-1140906-A1 | IMIDAZOLONES AND THEIR USE IN TREATING BENIGN PROSTATIC HYPERPLASIA AND OTHER DISORDERS | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035907-A1 | IMIDAZOLONES AND THEIR USE IN TREATING BENIGN PROSTATIC HYPERPLASIA AND OTHER DISORDERS | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2000-06-22 | — | — | WO | disclosed |
| US-6046331-A | Imidazolones and their use in treating benign prostatic hyperplasia and other disorders | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2000-04-04 | — | — | US | disclosed |