Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 2/20 | 0.56 |
| ▸ | CTSK | P43235 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.43 |
| ▸ | METAP1 | P53582 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | KLK7 | P49862 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL478905 | 0.88 | CTSS (0.68) | CTSSCTSKTSHRCA2EPHX2 | |
| SCHEMBL4395744 | 0.88 | CTSS (0.68) | CTSSCTSKTSHRCA2EPHX2 | |
| SCHEMBL352156 | 0.88 | CTSS (0.68) | CTSSCTSKTSHRCA2EPHX2 | |
| SCHEMBL1486229 | 0.88 | CTSS (0.68) | CTSSCTSKTSHRCA2EPHX2 | |
| Methanesulfonamide SCHEMBL6777577 | 0.83 | CTSS (0.60) | CTSSCTSKTSHRCA2EPHX2 | |
| Methanesulfonamide SCHEMBL6898028 | 0.83 | CTSS (0.60) | CTSSCTSKTSHRCA2EPHX2 | |
| Hydrochloric Acid SCHEMBL8461076 | 0.81 | CTSS (0.52) | CTSSCTSKTSHRCA2EPHX2 | |
| Hydrochloric Acid SCHEMBL8461075 | 0.81 | CTSS (0.52) | CTSSCTSKTSHRCA2EPHX2 | |
| SCHEMBL7874192 | 0.81 | CTSS (0.57) | CTSSCTSKTSHRCA2EPHX2 | |
| SCHEMBL7874195 | 0.81 | CTSS (0.57) | CTSSCTSKTSHRCA2EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1073633-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 2001-02-07 | — | — | EP | disclosed |
| WO-1999057098-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 1999-11-11 | — | — | WO | disclosed |