Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MIF | P14174 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12756966 | 0.78 | KMT2A (0.41) | KDM4EALDH1A1MIFKMT2A | |
| SCHEMBL23339919 | 0.77 | DPP4 (0.44) | DPP4F2ADRA2AADRA2CLMNA | |
| SCHEMBL25620243 | 0.76 | DPP4 (0.48) | DPP4F2ADRA2AADRA2CLMNA | |
| SCHEMBL27501005 | 0.72 | DPP4 (0.44) | DPP4F2ADRA2AADRA2CLMNA | |
| SCHEMBL28638696 | 0.72 | DPP4 (0.44) | DPP4F2ADRA2AADRA2CLMNA | |
| SCHEMBL9011583 | 0.72 | KMT2A (0.36) | LMNAALDH1A1MIFKMT2A | |
| SCHEMBL9011584 | 0.72 | KMT2A (0.36) | LMNAALDH1A1MIFKMT2A | |
| SCHEMBL9016418 | 0.72 | CYP1A2 (0.47) | LMNAALDH1A1KMT2A | |
| SCHEMBL2374243 | 0.69 | DPP4 (0.50) | DPP4F2ADRA2AADRA2CLMNA | |
| SCHEMBL6944728 | 0.66 | DPP4 (0.46) | DPP4F2ADRA2AADRA2CLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1012140-A1 | NEW AMIDINO DERIVATIVES AND THEIR USE AS THROMBIN INHIBITORS | AstraZeneca AB (SE) | 2000-06-28 | — | — | EP | disclosed |
| WO-1998057932-A1 | NEW AMIDINO DERIVATIVES AND THEIR USE AS THROMBIN INHIBITORS | ASTRA AKTIEBOLAG (SE) | 1998-12-23 | — | — | WO | disclosed |