Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 9/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | VCP | P55072 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12948668 | 0.81 | FLT3 (0.41) | HRH4HRH3BRD4 | |
| SCHEMBL7866429 | 0.79 | OPRL1 (0.57) | HRH4KDR | |
| SCHEMBL3062818 | 0.78 | FLT3 (0.44) | HRH4KDRBRD4 | |
| SCHEMBL16010504 | 0.76 | SMYD3 (0.43) | BRD4CHRNA7VCP | |
| SCHEMBL7501279 | 0.73 | HTR6 (0.44) | HRH4HRH3CHRNA7VCP | |
| SCHEMBL606634 | 0.73 | HRH4 (0.72) | HRH4HRH3 | |
| SCHEMBL4311651 | 0.72 | HRH4 (0.43) | HRH4HRH3KDR | |
| SCHEMBL6096901 | 0.72 | AOC3 (0.44) | HRH4BRD4 | |
| SCHEMBL6628802 | 0.69 | FLT3 (0.39) | HRH4BRD4 | |
| SCHEMBL5362383 | 0.69 | NR3C1 (0.40) | HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1196380-A2 | INDOLES AND INDAZOLES FOR THE TREATMENT OF MIGRAINE | NPS Allelix Corp. (CA) | 2002-04-17 | — | — | EP | disclosed |
| WO-2001005758-A2 | INDOLES AND INDAZOLES FOR THE TREATMENT OF MIGRAINE | NPS ALLELIX CORP. (CA) | 2001-01-25 | — | — | WO | disclosed |