Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | VCP | P55072 | 1/20 | 0.34 |
| ▸ | CCR1 | P32246 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7500375 | 0.73 | HRH4 (0.52) | CHRNA7HRH3VCPHRH4 | |
| SCHEMBL12948668 | 0.72 | FLT3 (0.41) | HRH3ALDH1A1HRH4 | |
| SCHEMBL6740915 | 0.71 | HTR6 (0.48) | HTR6CHRNA7HTR3ACNR2CCR1 | |
| SCHEMBL6426403 | 0.71 | HTR6 (0.48) | HTR6CHRNA7HTR3ACNR2CCR1 | |
| SCHEMBL16010504 | 0.71 | SMYD3 (0.43) | CHRNA7HTR3ACNR2VCPALDH1A1 | |
| SCHEMBL7866429 | 0.68 | OPRL1 (0.57) | ALDH1A1HRH4 | |
| SCHEMBL7498418 | 0.67 | PARP1 (0.42) | HTR6CHRNA7HRH3PARP1VCP | |
| SCHEMBL11372139 | 0.67 | CCR1 (0.44) | CCR1 | |
| SCHEMBL3062818 | 0.67 | FLT3 (0.44) | ALDH1A1HRH4 | |
| SCHEMBL7973508 | 0.66 | HRH3 (0.38) | CHRNA7HRH3VCPALDH1A1HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1196380-A2 | INDOLES AND INDAZOLES FOR THE TREATMENT OF MIGRAINE | NPS Allelix Corp. (CA) | 2002-04-17 | — | — | EP | disclosed |
| WO-2001005758-A2 | INDOLES AND INDAZOLES FOR THE TREATMENT OF MIGRAINE | NPS ALLELIX CORP. (CA) | 2001-01-25 | — | — | WO | disclosed |