Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CDK8 | P49336 | 2/20 | 0.42 |
| ▸ | CCNC | P24863 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
| ▸ | RXRG | P48443 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3176730 | 0.85 | CDK8 (0.46) | LMNAALDH1A1CDK8CCNCMAPK14 | |
| SCHEMBL15995545 | 0.83 | ALDH1A1 (0.56) | LMNAALDH1A1CDK8CCNCMAPK14 | |
| SCHEMBL378881 | 0.82 | CDK8 (0.63) | CDK8CCNCMAPK14MAPK13MAPK12 | |
| SCHEMBL27722384 | 0.81 | ALDH1A1 (0.39) | LMNAALDH1A1CDK8CCNCMAPK14 | |
| SCHEMBL3165072 | 0.81 | CDK8 (0.45) | LMNAALDH1A1CDK8CCNCMAPK14 | |
| SCHEMBL18593705 | 0.80 | ALDH1A1 (0.52) | LMNAALDH1A1MAPK14SMN1; SMN2NPSR1 | |
| SCHEMBL3174490 | 0.80 | CDK8 (0.53) | CDK8CCNCMAPK14MAPK13MAPK12 | |
| SCHEMBL27742974 | 0.80 | LMNA (0.38) | LMNAALDH1A1MAPK14SMN1; SMN2L3MBTL1 | |
| SCHEMBL3185815 | 0.80 | KCNJ6 (0.57) | CDK8CCNCMAPK14MAPK13MAPK12 | |
| SCHEMBL14539234 | 0.79 | CDK8 (0.43) | LMNAALDH1A1CDK8CCNCMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200411-A2 | NOVEL PROCESS FOR SYNTHESIS OF HETEROARYL-SUBSTITUTED UREA COMPOUNDS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2002-05-02 | — | — | EP | disclosed |
| WO-2001004115-A2 | NOVEL PROCESS FOR SYNTHESIS OF HETEROARYL-SUBSTITUTED UREA COMPOUNDS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2001-01-18 | — | — | WO | disclosed |