Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CTSD | P07339 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2085072 | 0.86 | TSHR (0.51) | TSHRSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL15906692 | 0.85 | TSHR (0.50) | TSHRSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL544031 | 0.84 | KMT2A (0.53) | TSHRSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL14249239 | 0.82 | SMN1; SMN2 (0.49) | TSHRSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL1421011 | 0.81 | ATR (0.52) | TSHRSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL30063181 | 0.81 | ATR (0.52) | TSHRSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL29959661 | 0.81 | TSHR (0.70) | TSHRSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL14933431 | 0.81 | TSHR (0.56) | TSHRSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL307312 | 0.81 | TSHR (0.70) | TSHRSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL195311 | 0.80 | ALDH1A1 (0.62) | TSHRSMN1; SMN2KMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1237888-A2 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | Bristol-Myers Squibb Company (US) | 2002-09-11 | — | — | EP | disclosed |
| WO-2001044239-A2 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | BRISTOL-MYERS SQUIBB CO. (US) | 2001-06-21 | — | — | WO | disclosed |