Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPSAB1 | Q15661 | 20/20 | 0.63 |
| ▸ | TPSD1 | Q9BZJ3 | 20/20 | 0.63 |
| ▸ | TPSG1 | Q9NRR2 | 20/20 | 0.63 |
| ▸ | PRSS1 | P07477 | 11/20 | 0.63 |
| ▸ | F2 | P00734 | 8/20 | 0.63 |
| ▸ | PLG | P00747 | 3/20 | 0.59 |
| ▸ | PRSS2 | P07478 | 7/20 | 0.52 |
| ▸ | PRSS3 | P35030 | 7/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7452526 | 0.91 | TPSAB1 (0.63) | TPSAB1TPSD1TPSG1PRSS1F2 | |
| SCHEMBL7441982 | 0.80 | TPSAB1 (0.77) | TPSAB1TPSD1TPSG1PRSS1F2 | |
| SCHEMBL7428430 | 0.76 | TPSAB1 (1.00) | TPSAB1TPSD1TPSG1PRSS1F2 | |
| SCHEMBL7501670 | 0.75 | LMNA (0.40) | — | |
| SCHEMBL7549698 | 0.75 | TPSAB1 (0.32) | TPSAB1TPSD1TPSG1PRSS1F2 | |
| SCHEMBL7499776 | 0.72 | TPSAB1 (0.76) | TPSAB1TPSD1TPSG1PRSS1F2 | |
| SCHEMBL7447628 | 0.72 | TPSAB1 (0.94) | TPSAB1TPSD1TPSG1PRSS1F2 | |
| SCHEMBL7446613 | 0.72 | TPSAB1 (0.94) | TPSAB1TPSD1TPSG1PRSS1F2 | |
| SCHEMBL7450373 | 0.71 | TPSAB1 (0.44) | TPSAB1TPSD1TPSG1PRSS1F2 | |
| SCHEMBL7550052 | 0.71 | TPSAB1 (0.65) | TPSAB1TPSD1TPSG1PRSS1F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934293-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR TREATING DISEASES ASSOCIATED WITH TRYPTASE ACTIVITY | ARRIS PHARMACEUTICAL CORPORATION (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998004537-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR TREATING DISEASES ASSOCIATED WITH TRYPTASE ACTIVITY | ARRIS PHARMACEUTICAL CORPORATION (US) | 1998-02-05 | — | — | WO | disclosed |