Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.32 |
| ▸ | TPSD1 | Q9BZJ3 | 2/20 | 0.32 |
| ▸ | TPSG1 | Q9NRR2 | 2/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
| ▸ | MLNR | O43193 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | NAMPT | P43490 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7543760 | 0.91 | TPSAB1 (0.37) | TPSAB1TPSD1TPSG1F2PRSS1 | |
| SCHEMBL7579428 | 0.82 | TPSAB1 (0.41) | TPSAB1TPSD1TPSG1F2PRSS1 | |
| SCHEMBL7501029 | 0.75 | TPSAB1 (0.63) | TPSAB1TPSD1TPSG1F2PRSS1 | |
| SCHEMBL7501670 | 0.72 | LMNA (0.40) | — | |
| SCHEMBL7498048 | 0.71 | TPSAB1 (0.45) | TPSAB1TPSD1TPSG1F2PRSS1 | |
| SCHEMBL7419360 | 0.70 | NAMPT (0.49) | TPSAB1TPSD1TPSG1F2PRSS1 | |
| SCHEMBL7452526 | 0.69 | TPSAB1 (0.63) | TPSAB1TPSD1TPSG1F2PRSS1 | |
| SCHEMBL7550052 | 0.66 | TPSAB1 (0.65) | TPSAB1TPSD1TPSG1F2PRSS1 | |
| SCHEMBL7543840 | 0.65 | TPSAB1 (0.53) | TPSAB1TPSD1TPSG1F2PRSS1 | |
| SCHEMBL7440324 | 0.64 | ALDH1A1 (0.39) | CYP3A4HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934293-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR TREATING DISEASES ASSOCIATED WITH TRYPTASE ACTIVITY | ARRIS PHARMACEUTICAL CORPORATION (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998004537-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR TREATING DISEASES ASSOCIATED WITH TRYPTASE ACTIVITY | ARRIS PHARMACEUTICAL CORPORATION (US) | 1998-02-05 | — | — | WO | disclosed |