Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 3/20 | 0.36 |
| ▸ | MMP9 | P14780 | 3/20 | 0.36 |
| ▸ | MMP8 | P22894 | 3/20 | 0.36 |
| ▸ | MMP13 | P45452 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7440324 | 0.89 | ALDH1A1 (0.39) | LMNAMAPTNPSR1HTR1AHTR7 | |
| SCHEMBL7449469 | 0.80 | ALDH1A1 (0.38) | LMNAMAPT | |
| SCHEMBL2896033 | 0.78 | TBXAS1 (0.49) | LMNAMAPT | |
| SCHEMBL26589771 | 0.78 | TBXAS1 (0.49) | LMNAMAPT | |
| SCHEMBL7451579 | 0.78 | DRD2 (0.41) | — | |
| SCHEMBL13779971 | 0.78 | KMT2A (0.43) | LMNAMAPT | |
| SCHEMBL291231 | 0.77 | TBXAS1 (0.46) | LMNAMAPT | |
| SCHEMBL7452641 | 0.75 | DRD2 (0.37) | NPSR1HTR7SIGMAR1 | |
| SCHEMBL7447625 | 0.74 | TBXAS1 (0.63) | LMNAMAPTNPSR1 | |
| SCHEMBL7357227 | 0.74 | CAPN1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934293-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR TREATING DISEASES ASSOCIATED WITH TRYPTASE ACTIVITY | ARRIS PHARMACEUTICAL CORPORATION (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998004537-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR TREATING DISEASES ASSOCIATED WITH TRYPTASE ACTIVITY | ARRIS PHARMACEUTICAL CORPORATION (US) | 1998-02-05 | — | — | WO | disclosed |