Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 9/20 | 0.48 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.45 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.42 |
| ▸ | MDH1 | P40925 | 1/20 | 0.42 |
| ▸ | MDH2 | P40926 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2388331 | 0.81 | HIF1A (0.49) | HIF1AEPAS1SERPINE1EPHX2MDH1 | |
| SCHEMBL9126429 | 0.80 | HIF1A (0.60) | HIF1AEPAS1SERPINE1EPHX2MDH1 | |
| SCHEMBL28094060 | 0.77 | SERPINE1 (0.50) | HIF1AEPAS1SERPINE1MDH1MDH2 | |
| SCHEMBL9124033 | 0.74 | SERPINE1 (0.55) | HIF1AEPAS1SERPINE1EPHX2MDH1 | |
| SCHEMBL422675 | 0.74 | SERPINE1 (0.58) | HIF1AEPAS1SERPINE1EPHX2KMT2A | |
| SCHEMBL3302845 | 0.73 | CES2 (0.56) | KMT2AALDH1A1MAPTNPC1 | |
| SCHEMBL11704336 | 0.73 | HIF1A (0.46) | HIF1AEPAS1EPHX2MDH1MDH2 | |
| SCHEMBL28197968 | 0.73 | HIF1A (0.55) | HIF1AEPAS1SERPINE1KMT2AMEN1 | |
| SCHEMBL941120 | 0.72 | TDP1 (0.62) | KMT2AMEN1MAPTHPGDNPC1 | |
| SCHEMBL27685314 | 0.71 | LOXL2 (0.43) | KMT2AMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0721942-B1 | TETRACYCLIC COMPOUND | KYOWA HAKKO KOGYO KK (JP) | 2002-06-05 | — | — | EP | disclosed |
| US-5646283-A | IMMUNOSUPPRESSANTS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-07-08 | — | — | US | disclosed |
| EP-0721942-A1 | NOVEL TETRACYCLIC COMPOUND | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1996-07-17 | — | — | EP | disclosed |