Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPSAB1 | Q15661 | 10/20 | 0.54 |
| ▸ | TPSD1 | Q9BZJ3 | 9/20 | 0.54 |
| ▸ | TPSG1 | Q9NRR2 | 9/20 | 0.54 |
| ▸ | PRSS1 | P07477 | 6/20 | 0.51 |
| ▸ | PRSS2 | P07478 | 5/20 | 0.51 |
| ▸ | PRSS3 | P35030 | 5/20 | 0.51 |
| ▸ | F2 | P00734 | 3/20 | 0.50 |
| ▸ | NAMPT | P43490 | 2/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.42 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | RBP4 | P02753 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7452959 | 0.85 | TPSAB1 (0.61) | TPSAB1TPSD1TPSG1PRSS1PRSS2 | |
| SCHEMBL7446751 | 0.77 | TPSAB1 (0.66) | TPSAB1TPSD1TPSG1PRSS1PRSS2 | |
| SCHEMBL12736124 | 0.75 | TPSAB1 (0.53) | TPSAB1TPSD1TPSG1ITGB3ITGA2B | |
| SCHEMBL7452781 | 0.74 | NAMPT (0.48) | TPSAB1TPSD1TPSG1PRSS1PRSS2 | |
| SCHEMBL304221 | 0.73 | SIGMAR1 (0.68) | L3MBTL3L3MBTL1 | |
| SCHEMBL7446694 | 0.73 | TPSAB1 (0.64) | TPSAB1TPSD1TPSG1PRSS1PRSS2 | |
| SCHEMBL26668519 | 0.72 | ITGB3 (0.67) | ITGB3ITGA2B | |
| SCHEMBL7447658 | 0.72 | TPSAB1 (0.76) | TPSAB1TPSD1TPSG1PRSS1PRSS2 | |
| SCHEMBL7446701 | 0.71 | TPSAB1 (0.72) | TPSAB1TPSD1TPSG1PRSS1PRSS2 | |
| SCHEMBL7447665 | 0.71 | TPSAB1 (0.82) | TPSAB1TPSD1TPSG1PRSS1PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934293-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR TREATING DISEASES ASSOCIATED WITH TRYPTASE ACTIVITY | ARRIS PHARMACEUTICAL CORPORATION (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998004537-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR TREATING DISEASES ASSOCIATED WITH TRYPTASE ACTIVITY | ARRIS PHARMACEUTICAL CORPORATION (US) | 1998-02-05 | — | — | WO | disclosed |