Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 3/20 | 0.35 |
| ▸ | HTR2C | P28335 | 3/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | HTR6 | P50406 | 4/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | PLG | P00747 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27999353 | 0.86 | CTSB (0.37) | CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL27600947 | 0.80 | LTA4H (0.41) | LTA4HCYP2D6PARP1SLC6A2SLC6A4 | |
| SCHEMBL2246688 | 0.80 | PLG (0.45) | LTA4HCYP2D6PARP1SLC6A2SLC6A4 | |
| SCHEMBL5557599 | 0.80 | SLC6A2 (0.45) | LTA4HCYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5557603 | 0.80 | SLC6A2 (0.45) | LTA4HCYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL22455764 | 0.78 | HTR6 (0.55) | HTR2AHTR6POLB | |
| SCHEMBL22122972 | 0.77 | PARP1 (0.43) | LTA4HCYP2D6PARP1SLC6A2SLC6A4 | |
| Acetic Acid SCHEMBL3512775 | 0.77 | LTA4H (0.38) | LTA4HCYP2D6PARP1SLC6A2SLC6A4 | |
| SCHEMBL28175982 | 0.76 | SLC6A2 (0.45) | CYP2D6SLC6A2SLC6A4HTR2CSLC6A3 | |
| SCHEMBL6076463 | 0.76 | ALDH1A1 (0.44) | LTA4HSLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242427-A1 | NOVEL PIPERIDINE AND PIPERAZINE DERIVATIVES | AstraZeneca AB (SE) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001046200-A1 | NOVEL PIPERIDINE AND PIPERAZINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-06-28 | — | — | WO | disclosed |