Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 10/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.52 |
| ▸ | HTR2C | P28335 | 8/20 | 0.52 |
| ▸ | DRD2 | P14416 | 4/20 | 0.52 |
| ▸ | HTR7 | P34969 | 7/20 | 0.46 |
| ▸ | HTR6 | P50406 | 6/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | CCR3 | P51677 | 2/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7551148 | 0.91 | HTR2A (0.57) | HTR2AKCNH2HTR2CDRD2HTR7 | |
| SCHEMBL7026575 | 0.82 | HTR7 (0.46) | HTR2AKCNH2HTR2CDRD2HTR7 | |
| SCHEMBL7502546 | 0.79 | MAOA (0.39) | KCNH2DRD2HTR7HTR6EPHX2 | |
| SCHEMBL7028441 | 0.73 | HTR2A (0.54) | HTR2AKCNH2HTR2CDRD2HTR7 | |
| SCHEMBL7034085 | 0.70 | MAOB (0.39) | DRD2HTR7HTR6EPHX2 | |
| SCHEMBL7497311 | 0.70 | CNR1 (0.42) | HTR2AKCNH2HTR2CDRD2CCR3 | |
| SCHEMBL3221937 | 0.66 | HSD11B1 (0.51) | — | |
| SCHEMBL7500901 | 0.65 | HTR2A (0.51) | HTR2AKCNH2HTR2CHTR7HTR6 | |
| SCHEMBL7025543 | 0.65 | HTR2A (0.52) | HTR2AKCNH2HTR2CDRD2EPHX2 | |
| SCHEMBL7024111 | 0.64 | HTR2A (0.60) | HTR2AKCNH2HTR2CDRD2HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246803-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES WHICH FUNCTION AS 5-HT 2A? RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001051469-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES WHICH FUNCTION AS 5-HT2A RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 2001-07-19 | — | — | WO | disclosed |