SCHEMBL7502803

SCHEMBL7502803

c1ccc(CN2CC3CCCC3Nc3ccccc32)cc1

nearest known ligand 0.49

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ALOX12 P18054 2/20 0.49
EPHX2 P34913 1/20 0.45
BRD4 O60885 3/20 0.41
SIRT1 Q96EB6 1/20 0.39
NISCH Q9Y2I1 1/20 0.37
OPRL1 P41146 1/20 0.36
LMNA P02545 2/20 0.35
TSHR P16473 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
MAPK1 P28482 1/20 0.35
TACR1 P25103 2/20 0.35
CACNA1G O43497 2/20 0.35
CACNA1H O95180 2/20 0.35
CACNA1I Q9P0X4 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7502809 1.00 ALOX12 (0.49) ALOX12EPHX2BRD4SIRT1NISCH
Hydrochloric Acid SCHEMBL7502494 0.99 ALOX12 (0.48) ALOX12EPHX2BRD4SIRT1NISCH
SCHEMBL2979728 0.73 SIGMAR1 (0.45) ALOX12BRD4SIRT1CACNA1GCACNA1H
SCHEMBL7496685 0.72 BRD4 (0.55) ALOX12BRD4SIRT1CACNA1GCACNA1H
SCHEMBL7496682 0.72 BRD4 (0.55) ALOX12BRD4SIRT1CACNA1GCACNA1H
SCHEMBL7955621 0.72 ALOX12 (0.48) ALOX12EPHX2BRD4SIRT1NISCH
Hydrochloric Acid SCHEMBL7504712 0.71 BRD4 (0.54) ALOX12BRD4SIRT1CACNA1GCACNA1H
SCHEMBL7496122 0.71 ALDH1A1 (0.57) EPHX2OPRL1LMNATSHR
SCHEMBL7496118 0.71 ALDH1A1 (0.57) EPHX2OPRL1LMNATSHR
SCHEMBL7817753 0.70 ALOX12 (0.52) ALOX12EPHX2BRD4SIRT1NISCH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0757681-B1 CONDENSED HETEROCYCLIC COMPOUNDS, THEIR PRODUCTION AND USE AS GnRH ANTAGONISTS TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2002-09-18 EP disclosed
EP-0757681-A1 CONDENSED HETEROCYCLIC COMPOUNDS, THEIR PRODUCTION AND USE AS GnRH ANTAGONISTS Takeda Chemical Industries, Ltd. (JP) 1997-02-12 EP disclosed
WO-1995029900-A1 CONDENSED HETEROCYCLIC COMPOUNDS, THEIR PRODUCTION AND USE AS GnRH ANTAGONISTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1995-11-09 WO disclosed