Sugi Predict

Sugi Predict / Compounds / SCHEMBL750324

SCHEMBL750324

SCHEMBL750324

COc1cccc(-c2ncco2)c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NOTUM Q6P988 2/20 0.58
▸ DYRK1A Q13627 1/20 0.57
▸ CLK4 Q9HAZ1 1/20 0.57
▸ NPC1 O15118 9/20 0.56
▸ RAB9A P51151 9/20 0.56
▸ SMN1; SMN2 Q16637 7/20 0.56
▸ HPGD P15428 5/20 0.56
▸ KDM4E B2RXH2 4/20 0.56
▸ ALDH1A1 P00352 4/20 0.56
▸ LTA4H P09960 1/20 0.53
▸ KMT2A Q03164 3/20 0.53
▸ TP53 P04637 4/20 0.51
▸ TDP1 Q9NUW8 3/20 0.51
▸ NFKB1 P19838 2/20 0.51
▸ NFKB2 Q00653 2/20 0.51
▸ RELA Q04206 2/20 0.51
▸ PKM P14618 1/20 0.51
▸ GRM5 P41594 1/20 0.51
▸ MAPT P10636 3/20 0.48
▸ MEN1 O00255 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11029318 0.84 S1PR1 (0.56) NOTUMNPC1RAB9ASMN1; SMN2HPGD
SCHEMBL31474610 0.83 LTA4H (0.47) NOTUMDYRK1ACLK4NPC1RAB9A
SCHEMBL9507190 0.82 LTA4H (0.73) NPC1RAB9ASMN1; SMN2LTA4HTP53
SCHEMBL3964365 0.82 HPGDS (0.58) NOTUMLTA4HHPGDS
SCHEMBL12251036 0.80 LTA4H (0.47) NOTUMDYRK1ACLK4NPC1RAB9A
SCHEMBL8853590 0.80 LTA4H (0.49) NOTUMDYRK1ACLK4NPC1RAB9A
SCHEMBL7260695 0.79 MAPKAPK2 (0.47) NOTUMDYRK1ACLK4NPC1RAB9A
SCHEMBL4314798 0.79 LTA4H (0.64) DYRK1ACLK4NPC1RAB9ASMN1; SMN2
SCHEMBL16159319 0.78 HPGDS (0.55) NOTUMLTA4HHPGDS
SCHEMBL5185084 0.78 LTA4H (0.44) NOTUMNPC1SMN1; SMN2HPGDKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107793374-A A kind of preparation method of 2 bromine 1 (3 methoxyphenyl) oxazoles 湖南华腾制药有限公司 2018-03-13 — — CN claimed
CN-107266505-B Tetradentate ring metal platinum (II) complex phosphorescence luminescent material 浙江工业大学 2021-11-23 — — CN disclosed
CN-107417733-B Quadridentate ring metal palladium (II) complex phosphorescence luminescent material 浙江工业大学 2020-10-27 — — CN disclosed
CN-107793374-A A kind of preparation method of 2 bromine 1 (3 methoxyphenyl) oxazoles 湖南华腾制药有限公司 2018-03-13 — — CN disclosed
CN-107793374-A A kind of preparation method of 2 bromine 1 (3 methoxyphenyl) oxazoles 湖南华腾制药有限公司 2018-03-13 — — CN disclosed
CN-107793374-A A kind of preparation method of 2 bromine 1 (3 methoxyphenyl) oxazoles 湖南华腾制药有限公司 2018-03-13 — — CN disclosed
CN-107417733-A Quadridentate ring metal palladium (II) complex phosphorescence luminescent material 浙江工业大学 2017-12-01 — — CN disclosed
CN-107266505-A Tetradentate ring metal platinum (II) complex phosphorescence luminescent material 浙江工业大学 2017-10-20 — — CN disclosed
US-8569285-B2 Dihydrobenzoxathiazepine compounds, a process for their preparation and pharmaceutical compositions containing them LES LABORATOIRES SERVIER (FR) 2013-10-29 — — US disclosed
EP-2431360-B1 Derivatives of dihydrobenzoxathiazepine, method of preparing same and pharmaceutical compositions containing them as well as their uses as modulators of AMPA receptors SERVIER LAB (FR) 2013-04-17 — — EP disclosed
US-20120071462-A1 Dihydrobenzoxathiazepine compounds, a process for their preparation and pharmaceutical compositions containing them LES LABORATOIRES SERVIER (FR) 2012-03-22 — — US disclosed
WO-2012035216-A1 DIHYDROBENZOXATHIAZEPINE DERIVATIVES, PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS AND USE AS AMPA RECEPTOR MODULATORS LES LABORATOIRES SERVIER (FR) 2012-03-22 — — WO disclosed
EP-2431360-A1 Derivatives of dihydrobenzoxathiazepine, method of preparing same and pharmaceutical compositions containing them as well as their uses as modulators of AMPA receptors Les Laboratoires Servier (FR) 2012-03-21 — — EP disclosed
US-20110237784-A1 10A-AZALIDE COMPOUND CROSSLINKED AT 10A- AND 12-POSITIONS TAISHO PHARMACEUTICAL CO., LTD. (JP) 2011-09-29 — — US disclosed
WO-2008129129-A1 HETEROCYCLIC PHENYL CARBAMATES AS NOVEL FAAH-INHIBITORS KUOPION YLIOPISTO (FI) 2008-10-30 — — WO disclosed
US-5476758-A Film thickness; spectral sensitizer FUJI PHOTO FILM CO., LTD. (JP) 1995-12-19 — — US disclosed
EP-0297804-B1 SILVER HALIDE PHOTOGRAPHIC LIGHT-SENSITIVE MATERIAL KONICA CORPORATION (JP) 1993-08-18 — — EP disclosed
US-4863846-A SULFUR KONICA CORPORATION (JP) 1989-09-05 — — US disclosed
EP-0297804-A2 Silver halide photographic light-sensitive material KONICA CORPORATION (JP) 1989-01-04 — — EP disclosed
US-4168379-A Pyridin-3-ols BASF AKTIENGESELLSCHAFT (DE) 1979-09-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110237784-A1 10A-AZALIDE COMPOUND CROSSLINKED AT 10A- AND 12-POSITIONS DCLRE1A, AZI2, CHD9 NOTUM 3307/4885DYRK1A 3675/4885CLK4 4600/4885
US-20120071462-A1 Dihydrobenzoxathiazepine compounds, a process for their preparation and pharmaceutical compositions containing them GABRA1, GRM1, GABRA5 NOTUM 2428/4885DYRK1A 2109/4885CLK4 4114/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.