SCHEMBL7504485

SCHEMBL7504485

N#Cc1cc(O)c2[nH]c(=O)oc2c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOS3 P29474 1/20 0.49
NOS1 P29475 1/20 0.49
NOS2 P35228 1/20 0.49
GRM5 P41594 1/20 0.43
PTPN11 Q06124 1/20 0.36
GPR35 Q9HC97 1/20 0.35
AR P10275 2/20 0.35
HCRTR1 O43613 1/20 0.33
HCRTR2 O43614 1/20 0.33
MIF P14174 1/20 0.33
CA9 Q16790 1/20 0.33
ALPL P05186 1/20 0.33
XDH P47989 3/20 0.33
SLC22A12 Q96S37 3/20 0.33
MCL1 Q07820 1/20 0.33
KMO O15229 1/20 0.33
TTR P02766 2/20 0.32
ALB P02768 2/20 0.32
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3058058 0.69 NOS1 (0.75) NOS3NOS1NOS2GRM5ALPL
SCHEMBL1137634 0.66 PSMB8 (0.61) GRM5MCL1
SCHEMBL1423023 0.66 NOS1 (1.00) NOS3NOS1NOS2GRM5ALPL
SCHEMBL2904782 0.65 NOS3 (0.40) NOS3NOS1NOS2GRM5XDH
SCHEMBL14698490 0.65 FASN (0.47) NOS3NOS1NOS2GRM5GPR35
SCHEMBL4247434 0.64 GRM5 (0.38) NOS3NOS1NOS2GRM5MCL1
SCHEMBL11761629 0.63 MCL1 (0.50) NOS3NOS1NOS2GRM5MCL1
SCHEMBL1285358 0.63 KDR (0.45) NOS3NOS1NOS2GRM5CA9
SCHEMBL18585275 0.62 XDH (0.54) PTPN11GPR35ARXDHSLC22A12
SCHEMBL6689589 0.62 GRM5 (0.48) NOS3NOS1NOS2GRM5HCRTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1107949-A4 PROCESS FOR PREPARING CERTAIN PHENYL UREA COMPOUNDS SMITHKLINE BEECHAM CORP (US) 2002-08-07 EP disclosed
US-6372933-B1 REACTING BENZOXAZOLINONE WITH NUCLEOPHILIC ANILINE DERIVATIVE IN PRESENCE OF LEWIS ACID TO OPEN OXAZOLINONE RING TO FORM PHENYL UREA COMPOUND SMITHKLINE BEECHAM CORPORATION 2002-04-16 US disclosed
EP-1107948-A4 AN IMPROVED SYNTHESIS OF 3-HYDROXY-4-AMINO-BENZONITRILE SMITHKLINE BEECHAM (US) 2002-01-02 EP disclosed
EP-1107949-A2 PROCESS FOR PREPARING CERTAIN PHENYL UREA COMPOUNDS SMITHKLINE BEECHAM CORPORATION (US) 2001-06-20 EP disclosed
EP-1107948-A1 AN IMPROVED SYNTHESIS OF 3-HYDROXY-4-AMINO-BENZONITRILE Smithkline Beecham (US) 2001-06-20 EP disclosed
WO-2000012472-A2 PROCESS FOR PREPARING CERTAIN PHENYL UREA COMPOUNDS SMITHKLINE BEECHAM CORPORATION (US) 2000-03-09 WO disclosed
WO-2000012468-A1 AN IMPROVED SYNTHESIS OF 3-HYDROXY-4-AMINO-BENZONITRILE SMITHKLINE BEECHAM CORPORATION (US) 2000-03-09 WO disclosed