SCHEMBL7508446

SCHEMBL7508446

CCOC(=O)C1=Cc2ccc(F)cc2N=C(N)C1

nearest known ligand 0.62

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TLR8 Q9NR97 20/20 0.62
TLR7 Q9NYK1 9/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7509353 0.90 TLR8 (0.54) TLR8TLR7
SCHEMBL3032882 0.86 TLR8 (0.61) TLR8TLR7
SCHEMBL7505631 0.86 TLR8 (0.63) TLR8TLR7
SCHEMBL22771214 0.85 TLR8 (0.60) TLR8TLR7
SCHEMBL8179545 0.85 TLR8 (0.60) TLR8TLR7
SCHEMBL8191084 0.85 TLR8 (0.60) TLR8TLR7
SCHEMBL22771262 0.84 TLR8 (0.59) TLR8TLR7
SCHEMBL1104739 0.84 TLR8 (0.56) TLR8TLR7
SCHEMBL12619280 0.82 TLR8 (0.68) TLR8TLR7
SCHEMBL12619283 0.82 TLR8 (0.71) TLR8TLR7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0825186-B1 2-Aminobenzazepine derivatives and their use for the treatment of immunosuppression PFIZER (US) 2002-04-17 EP disclosed