SCHEMBL22771214

SCHEMBL22771214

CCOC(=O)C1=Cc2ccc(C(=O)O)cc2N=C(N)C1

nearest known ligand 0.60

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TLR8 Q9NR97 20/20 0.60
TLR7 Q9NYK1 8/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8191084 0.91 TLR8 (0.60) TLR8TLR7
SCHEMBL22771140 0.86 TLR8 (0.72) TLR8TLR7
SCHEMBL7508446 0.85 TLR8 (0.62) TLR8TLR7
SCHEMBL22790540 0.85 TLR8 (0.72) TLR8TLR7
SCHEMBL3032882 0.84 TLR8 (0.61) TLR8TLR7
SCHEMBL7505631 0.84 TLR8 (0.63) TLR8TLR7
SCHEMBL8179545 0.83 TLR8 (0.60) TLR8TLR7
SCHEMBL233010 0.83 TLR8 (0.66) TLR8TLR7
SCHEMBL22783803 0.82 TLR8 (0.69) TLR8TLR7
SCHEMBL11961332 0.82 TLR8 (0.65) TLR8TLR7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12570610-B2 Macromolecule-supported aminobenzazepine compounds BOLT BIOTHERAPEUTICS, INC. (US) 2026-03-10 US disclosed
US-20250263392-A1 AMINOBENZAZEPINE COMPOUNDS, IMMUNOCONJUGATES, AND USES THEREOF BOLT BIOTHERAPEUTICS, INC. (US) 2025-08-21 US disclosed
US-20220347310-A1 AMIDE-LINKED, AMINOBENZAZEPINE IMMUNOCONJUGATES, AND USES THEREOF BOLT BIOTHERAPEUTICS, INC. (US) 2022-11-03 US disclosed
US-20220315537-A1 MACROMOLECULE-SUPPORTED AMINOBENZAZEPINE COMPOUNDS BOLT BIOTHERAPEUTICS, INC. (US) 2022-10-06 US disclosed
EP-4038053-A1 AMIDE-LINKED, AMINOBENZAZEPINE IMMUNOCONJUGATES, AND USES THEREOF Bolt Biotherapeutics, Inc. (US) 2022-08-10 EP disclosed
CN-114585390-A Aminobenzazepine compounds, immunoconjugates and uses thereof 博尔特生物治疗药物有限公司 2022-06-03 CN disclosed
EP-3983082-A1 AMINOBENZAZEPINE COMPOUNDS, IMMUNOCONJUGATES, AND USES THEREOF Bolt Biotherapeutics, Inc. (US) 2022-04-20 EP disclosed
EP-3983080-A1 MACROMOLECULE-SUPPORTED AMINOBENZAZEPINE COMPOUNDS Bolt Biotherapeutics, Inc. (US) 2022-04-20 EP disclosed
WO-2021067242-A1 AMIDE-LINKED, AMINOBENZAZEPINE IMMUNOCONJUGATES, AND USES THEREOF BOLT BIOTHERAPEUTICS, INC. (US) 2021-04-08 WO disclosed
WO-2021067242-A1 AMIDE-LINKED, AMINOBENZAZEPINE IMMUNOCONJUGATES, AND USES THEREOF BOLT BIOTHERAPEUTICS, INC. (US) 2021-04-08 WO disclosed
WO-2020252294-A1 AMINOBENZAZEPINE COMPOUNDS, IMMUNOCONJUGATES, AND USES THEREOF BOLT BIOTHERAPEUTICS, INC. (US) 2020-12-17 WO disclosed
WO-2020252254-A1 MACROMOLECULE-SUPPORTED AMINOBENZAZEPINE COMPOUNDS BOLT BIOTHERAPEUTICS, INC. (US) 2020-12-17 WO disclosed
WO-2020252254-A1 MACROMOLECULE-SUPPORTED AMINOBENZAZEPINE COMPOUNDS BOLT BIOTHERAPEUTICS, INC. (US) 2020-12-17 WO disclosed
WO-2020252294-A1 AMINOBENZAZEPINE COMPOUNDS, IMMUNOCONJUGATES, AND USES THEREOF BOLT BIOTHERAPEUTICS, INC. (US) 2020-12-17 WO disclosed
US-20200390899-A1 AMINOBENZAZEPINE COMPOUNDS, IMMUNOCONJUGATES, AND USES THEREOF BOLT BIOTHERAPEUTICS, INC. (US) 2020-12-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250263392-A1 AMINOBENZAZEPINE COMPOUNDS, IMMUNOCONJUGATES, AND USES THEREOF IDO2, IDO1, BCR TLR8 3275/4885TLR7 1547/4885
US-20220315537-A1 MACROMOLECULE-SUPPORTED AMINOBENZAZEPINE COMPOUNDS CCNB1, CCNB2, MUS81 TLR8 3652/4885TLR7 4387/4885
US-20200390899-A1 AMINOBENZAZEPINE COMPOUNDS, IMMUNOCONJUGATES, AND USES THEREOF IDO2, IDO1, BCR TLR8 3275/4885TLR7 1547/4885
US-20220347310-A1 AMIDE-LINKED, AMINOBENZAZEPINE IMMUNOCONJUGATES, AND USES THEREOF AADAC, IGLV6-57, BCR TLR8 535/4885TLR7 608/4885
US-12570610-B2 Macromolecule-supported aminobenzazepine compounds BCL6, CLTB, MET TLR8 2517/4885TLR7 3346/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.