SCHEMBL7510280

SCHEMBL7510280

Nc1ccccc1CN1CC[N]CC1

nearest known ligand 0.44

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MPO P05164 1/20 0.44
SIGMAR1 Q99720 3/20 0.42
ALDH1A1 P00352 3/20 0.41
KMT2A Q03164 1/20 0.40
CXCR4 P61073 1/20 0.39
CYP2A13 Q16696 5/20 0.39
ROCK2 O75116 1/20 0.38
CCR2 P41597 1/20 0.38
ROCK1 Q13464 1/20 0.38
MAPT P10636 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
LMNA P02545 1/20 0.38
KDM4E B2RXH2 1/20 0.38
PLA2G1B P04054 1/20 0.38
RAB9A P51151 1/20 0.38
ATG4B Q9Y4P1 1/20 0.38
ACHE P22303 1/20 0.38
POLB P06746 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14407776 0.86 MPO (0.57) MPOSIGMAR1ALDH1A1KMT2ACXCR4
SCHEMBL1641681 0.82 ALDH1A1 (0.58) MPOSIGMAR1ALDH1A1KMT2ASMN1; SMN2
SCHEMBL2912056 0.81 ALDH1A1 (0.61) MPOSIGMAR1ALDH1A1KMT2ASMN1; SMN2
SCHEMBL27535071 0.79 MPO (0.46) MPOSIGMAR1ALDH1A1KMT2ACXCR4
SCHEMBL916891 0.78 ALDH1A1 (0.68) MPOSIGMAR1ALDH1A1KMT2ACYP2A13
SCHEMBL3967331 0.78 KMT2A (0.66) ALDH1A1KMT2ACYP2A13TDP1LMNA
SCHEMBL4060263 0.78 CYP2A13 (0.64) MPOALDH1A1KMT2ACYP2A13KDM4E
SCHEMBL3412153 0.78 MC4R (0.56) MPOSIGMAR1ALDH1A1KMT2ASMN1; SMN2
SCHEMBL2338990 0.78 CYP2A13 (0.64) ALDH1A1KMT2ACXCR4CYP2A13MAPT
SCHEMBL1578951 0.78 SIGMAR1 (0.66) SIGMAR1ALDH1A1KMT2ACXCR4CYP2A13

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0823413-B1 Intermediates for the preparation of benzoheterocyclic compounds OTSUKA PHARMA CO LTD (JP) 2002-02-13 EP disclosed
US-5811576-A 1-CARBOXY-2-LOWERALKYL-3,4,6-TRI(HALO)BENZENES; GRAMPOSITIVE AND-NEGATIVE BACTERIA; INFECTIONS; STERILIZATION OF MEDICAL EQUIPMENT OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) 1998-09-22 US disclosed
US-5723648-A Intermediates for anti-microbial benzoheterocyclic compounds OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) 1998-03-03 US disclosed
EP-0823413-A2 Benzoheterocyclic compounds OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1998-02-11 EP disclosed
US-5591744-A 1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLATE DERIVATIVES; MICROBIOCIDES OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) 1997-01-07 US disclosed
US-5563138-A 4-OXOQUINOLINE-3-CARBOXYLIC ACID COMPOUNDS HAVING ANTIMICROBIAL ACTIVITY OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) 1996-10-08 US disclosed
EP-0287951-B1 7-Piperazinyl- or 7-Morpholino-4-oxo-quinoline-3-carboxylic acid derivatives, their preparation and their use as antimicrobial agents OTSUKA PHARMA CO LTD (JP) 1996-07-03 EP disclosed
US-5495020-A CHEMICAL INTERMEDIATE FOR BACTERICIDES, MICROBIOCIDES, DISINFECTANTS; SIDE EFFECT REDUCTION, ABSORPTION OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) 1996-02-27 US disclosed
US-5290934-A Benzoheterocyclic compounds OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) 1994-03-01 US disclosed
EP-0565132-A2 Benzoheterocyclic compounds OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1993-10-13 EP disclosed
EP-0287951-A2 7-Piperazinyl- or 7-Morpholino-4-oxo-quinoline-3-carboxylic acid derivatives, their preparation and their use as antimicrobial agents OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1988-10-26 EP disclosed