Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 10/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | STAT1 | P42224 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL753041 | 0.83 | NFE2L2 (0.49) | NFE2L2SMN1; SMN2LMNAKDM4EPTK2 | |
| SCHEMBL1124256 | 0.83 | NFE2L2 (0.49) | NFE2L2SMN1; SMN2LMNAKDM4EPTK2 | |
| SCHEMBL3310811 | 0.81 | NFE2L2 (0.47) | NFE2L2SMN1; SMN2LMNAMAPTKDM4E | |
| SCHEMBL732497 | 0.77 | TRPA1 (0.43) | NFE2L2SMN1; SMN2LMNAMAPTKDM4E | |
| SCHEMBL9944607 | 0.76 | MAPT (0.46) | SMN1; SMN2LMNAMAPTKDM4ECYP1A2 | |
| SCHEMBL9944613 | 0.75 | KDM4E (0.45) | SMN1; SMN2LMNAMAPTKDM4ECYP1A2 | |
| SCHEMBL27640623 | 0.75 | PTK2 (0.49) | NFE2L2SMN1; SMN2PTK2TDP1L3MBTL1 | |
| Trifluoroacetic Acid SCHEMBL732103 | 0.75 | NFE2L2 (0.42) | NFE2L2SMN1; SMN2LMNAKDM4ECYP1A2 | |
| Trifluoroacetic Acid SCHEMBL732105 | 0.75 | NFE2L2 (0.42) | NFE2L2SMN1; SMN2LMNAKDM4ECYP1A2 | |
| SCHEMBL74727 | 0.74 | NFE2L2 (0.50) | NFE2L2PTK2TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138188-B2 | Melanocortin type 4 receptor agonist piperidinoylpyrrolidines | PFIZER INC. (US) | 2012-03-20 | — | — | US | disclosed |