Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 10/20 | 0.50 |
| ▸ | APLNR | P35414 | 1/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1311523 | 0.84 | — | — | |
| SCHEMBL74725 | 0.77 | NFE2L2 (0.50) | NFE2L2PTK2ADRA2AADRA2BADRA2C | |
| SCHEMBL74726 | 0.77 | NFE2L2 (0.50) | NFE2L2PTK2ADRA2AADRA2BADRA2C | |
| SCHEMBL9000499 | 0.76 | NFE2L2 (0.49) | NFE2L2ADRA2AADRA2BADRA2CL3MBTL1 | |
| SCHEMBL13939196 | 0.74 | APLNR (0.50) | APLNRADRA2AADRA2BADRA2CPLAU | |
| SCHEMBL7242160 | 0.74 | APLNR (0.50) | APLNRADRA2AADRA2BADRA2CPLAU | |
| SCHEMBL733566 | 0.74 | — | — | |
| SCHEMBL7242156 | 0.74 | APLNR (0.50) | APLNRADRA2AADRA2BADRA2CPLAU | |
| SCHEMBL266083 | 0.74 | — | — | |
| SCHEMBL18921504 | 0.74 | NFE2L2 (0.51) | NFE2L2PTK2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9045422-B2 | Piperidine derivatives with pesticidal properties | SYNGENTA PARTICIPATIONS AG (CH) | 2015-06-02 | — | — | US | disclosed |
| US-8846907-B2 | Spiro-condensed indoline derivatives as pesticides | SYNGENTA CROP PROTECTION LLC (US) | 2014-09-30 | — | — | US | disclosed |
| US-8796274-B2 | Piperazine derivatives and their use in controlling pests | SYNGENTA CROP PROTECTION LLC (US) | 2014-08-05 | — | — | US | disclosed |
| US-20140179921-A1 | CHEMICAL COMPOUNDS | SYNGENTA CROP PROTECTION LLC (US) | 2014-06-26 | — | — | US | disclosed |
| US-20140031378-A1 | INSECTICIDAL SPIRONINDANE DERIVATIVES | SYNGENTA CROP PROTECTION LLC | 2014-01-30 | — | — | US | disclosed |
| US-20130310399-A1 | CHEMICAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2013-11-21 | — | — | US | disclosed |
| US-8546569-B2 | Chemical compounds | SYNGENTA CROP PROTECTION, INC. (US) | 2013-10-01 | — | — | US | disclosed |
| US-20130197029-A1 | CHEMICAL COMPOUNDS | SYNGENTA CROP PROTECTION LLC (US) | 2013-08-01 | — | — | US | disclosed |
| EP-1763302-B1 | CHEMICAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2013-03-06 | — | — | EP | disclosed |
| US-20130046091-A1 | SPIRO-CONDENSED INDOLINE DERIVATIVES AS PESTICIDES | SYNGENTA CROP PROTECTION LLC (US) | 2013-02-21 | — | — | US | disclosed |
| EP-1694676-B1 | SPIROINDOLINE DERIVATIVES HAVING INSECTICIDAL PROPERTIES | SYNGENTA PARTICIPATIONS AG (CH) | 2009-08-26 | — | — | EP | disclosed |
| US-20090118295-A1 | CHEMICAL COMPOUNDS | SYNGENTA CROP PROTECTION, INC (US) | 2009-05-07 | — | — | US | disclosed |
| US-20090042921-A1 | SPIROINDOLINE DERIVATIVES HAVING INSECTICIDAL PROPERTIES | SYNGENTA PARTICIPATIONS AG (CH) | 2009-02-12 | — | — | US | disclosed |
| US-20090042859-A1 | SPIRO-CONDENSED INDOLINE DERIVATIVES AS PESTICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2009-02-12 | — | — | US | disclosed |
| US-20090042938-A1 | Chemical Compounds | SYNGENTA CROP PROTECTION, INC. (US) | 2009-02-12 | — | — | US | disclosed |
| US-20080306101-A1 | Insecticidal Spironindane Derivatives | SYNGENTA PARTICIPATIONS AG (CH) | 2008-12-11 | — | — | US | disclosed |
| EP-1697376-B1 | SPIRO-CONDENSED INDOLINE DERIVATIVES AS PESTICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2008-06-18 | — | — | EP | disclosed |
| US-20080076777-A1 | 2-chloro-N-(4-chloro-2-{4-[(E)-3-(4-chloro-phenyl)-allyl]-piperazin-1-yl}-phenyl)-isonicotinamide; for insects, acarines, nematodes and molluscs | SYNGENTA CROP PROTECTION, INC. (US) | 2008-03-27 | — | — | US | disclosed |
| US-20070225269-A1 | Use of (3-(1-(3-Phenyl-Propenyl)-Piperidin-4-Yl)-2,3-Dihydro-Indol-1-Yl)-(Pyridin-4-Yl)-Methanonone Derivatives and Related Compounds as Insecticides | SYNGENTA CROP PROTECTION, INC. | 2007-09-27 | — | — | US | disclosed |
| US-20070135408-A1 | Spiropiperidine derivatives for controlling pests | SYNGENTA CROP PROTECTION, INC. | 2007-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042938-A1 | Chemical Compounds | CHRM1, MRM1, H1-0 | NFE2L2 1218/4885APLNR 2002/4885PTK2 3619/4885 |
| US-20130197029-A1 | CHEMICAL COMPOUNDS | MRM1, H1-0, RO60 | NFE2L2 1211/4885APLNR 1936/4885PTK2 3679/4885 |
| US-20080076777-A1 | 2-chloro-N-(4-chloro-2-{4-[(E)-3-(4-chloro-phenyl)-allyl]-piperazin-1-yl}-phenyl)-isonicotinamide; for insects, acarines, nematodes and molluscs | CHRM1, CHRM2, CHRM5 | NFE2L2 926/4885APLNR 116/4885PTK2 3908/4885 |
| US-20090042921-A1 | SPIROINDOLINE DERIVATIVES HAVING INSECTICIDAL PROPERTIES | CHRM1, CHRM2, ACHE | NFE2L2 684/4885APLNR 4427/4885PTK2 3113/4885 |
| US-20140179921-A1 | CHEMICAL COMPOUNDS | H1-0, REL, ZYX | NFE2L2 169/4885APLNR 3307/4885PTK2 3480/4885 |
| US-20090042859-A1 | SPIRO-CONDENSED INDOLINE DERIVATIVES AS PESTICIDES | CHRM1, CHRM2, RO60 | NFE2L2 859/4885APLNR 2793/4885PTK2 2211/4885 |
| US-20080306101-A1 | Insecticidal Spironindane Derivatives | NR1D1, NR1D2, NR1I3 | NFE2L2 1589/4885APLNR 938/4885PTK2 2251/4885 |
| US-20070135408-A1 | Spiropiperidine derivatives for controlling pests | CHRM1, CHRM2, RER1 | NFE2L2 1989/4885APLNR 2947/4885PTK2 2939/4885 |
| US-20140031378-A1 | INSECTICIDAL SPIRONINDANE DERIVATIVES | NR1D1, NR1D2, NR1I3 | NFE2L2 1589/4885APLNR 938/4885PTK2 2251/4885 |
| US-20070225269-A1 | Use of (3-(1-(3-Phenyl-Propenyl)-Piperidin-4-Yl)-2,3-Dihydro-Indol-1-Yl)-(Pyridin-4-Yl)-Methanonone Derivatives and Related Compounds as Insecticides | CHRM1, NPY1R, MRM1 | NFE2L2 2691/4885APLNR 1447/4885PTK2 2100/4885 |
| US-20130046091-A1 | SPIRO-CONDENSED INDOLINE DERIVATIVES AS PESTICIDES | CHRM1, CHRM2, CHRM3 | NFE2L2 929/4885APLNR 2622/4885PTK2 2142/4885 |
| US-20130310399-A1 | CHEMICAL COMPOUNDS | ACHE, CHRM1, CHRM2 | NFE2L2 2622/4885APLNR 2644/4885PTK2 3855/4885 |
| US-20090118295-A1 | CHEMICAL COMPOUNDS | MRM1, MNS1, CHRM1 | NFE2L2 1014/4885APLNR 2236/4885PTK2 3384/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.