Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | PNMT | P11086 | 7/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7442659 | 0.75 | CACNA1C (0.41) | MAPTALDH1A1L3MBTL1CHRNB2CHRNB4 | |
| SCHEMBL7436130 | 0.75 | CACNA1C (0.41) | MAPTALDH1A1L3MBTL1CHRNB2CHRNB4 | |
| SCHEMBL13224204 | 0.74 | MAPT (0.47) | MAPTALDH1A1PNMTADRA2AADRA2B | |
| SCHEMBL3417137 | 0.74 | MAPT (0.47) | MAPTALDH1A1PNMTADRA2AADRA2B | |
| SCHEMBL6799096 | 0.74 | MAPT (0.49) | MAPTALDH1A1L3MBTL1CHRNB2CHRNB4 | |
| SCHEMBL7432582 | 0.74 | ALDH1A1 (0.40) | MAPTALDH1A1L3MBTL1CHRNB2CHRNB4 | |
| SCHEMBL3604041 | 0.72 | ALDH1A1 (0.55) | MAPTALDH1A1L3MBTL1PNMTADRA2A | |
| SCHEMBL1202143 | 0.72 | PNMT (0.61) | PNMTADRA2AADRA2BADRA2C | |
| Hydrochloric Acid SCHEMBL2081344 | 0.71 | PNMT (0.60) | PNMTADRA2AADRA2BADRA2C | |
| Hydrochloric Acid SCHEMBL2081340 | 0.71 | PNMT (0.60) | PNMTADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0861250-B1 | AMIDINE AND ISOTHIOUREA DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHASE | ASTRAZENECA AB (SE) | 2002-02-13 | — | — | EP | disclosed |
| US-6140322-A | Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase | ASTRA AKTIEBOLAG (SE) | 2000-10-31 | — | — | US | disclosed |
| US-5929085-A | Amidine and isothiourea derivatives, compositions containing them and their use as inhibitors of nitric oxide synthase | ASTRA AKTIEBOLAG (SE) | 1999-07-27 | — | — | US | disclosed |
| EP-0861250-A1 | AMIDINE AND ISOTHIOUREA DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHASE | Astra Aktiebolag (SE) | 1998-09-02 | — | — | EP | disclosed |
| WO-1997017344-A1 | AMIDINE AND ISOTHIOUREA DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHASE | ASTRA AKTIEBOLAG (SE) | 1997-05-15 | — | — | WO | disclosed |