SCHEMBL7511613

SCHEMBL7511613

CCOC(=O)c1cn([C@@H]2C[C@H]2F)c2c(C)c(F)c(F)cc2c1=O

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
STAT3 P40763 2/20 0.51
ADRB2 P07550 1/20 0.50
KMT2A Q03164 3/20 0.45
CNR1 P21554 1/20 0.43
CNR2 P34972 1/20 0.43
KDM4E B2RXH2 3/20 0.43
HPGD P15428 3/20 0.43
ALDH1A1 P00352 2/20 0.43
HSD17B10 Q99714 2/20 0.43
HTT P42858 1/20 0.41
KCNH2 Q12809 2/20 0.40
CYP2C19 P33261 1/20 0.39
LMNA P02545 1/20 0.38
TOP2A P11388 1/20 0.38
TOP2B Q02880 1/20 0.38
MEN1 O00255 1/20 0.38
MAPT P10636 1/20 0.38
THRB P10828 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
CYP3A4 P08684 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7511615 1.00 STAT3 (0.51) STAT3ADRB2KMT2ACNR1CNR2
SCHEMBL13483643 1.00 STAT3 (0.51) STAT3ADRB2KMT2ACNR1CNR2
SCHEMBL10365215 0.94 STAT3 (0.55) STAT3ADRB2KMT2ACNR1CNR2
SCHEMBL13483612 0.92 STAT3 (0.49) STAT3ADRB2KMT2ACNR1CNR2
SCHEMBL3186787 0.92 STAT3 (0.49) STAT3ADRB2KMT2ACNR1CNR2
SCHEMBL3186793 0.92 STAT3 (0.49) STAT3ADRB2KMT2ACNR1CNR2
SCHEMBL2670291 0.90 ADRB2 (0.47) STAT3ADRB2KMT2ACNR1CNR2
SCHEMBL15828541 0.90 ADRB2 (0.47) STAT3ADRB2KMT2ACNR1CNR2
SCHEMBL9097566 0.90 STAT3 (0.49) STAT3ADRB2KMT2ACNR1CNR2
SCHEMBL9097561 0.90 STAT3 (0.49) STAT3ADRB2KMT2ACNR1CNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20020193591-A1 Process for producing 5-amino-8-alkylquinolonecarboxylic acid derivative and intermediates in the production thereof DAIICHI PHARMACEUTICAL CO., LTD. 2002-12-19 US disclosed
EP-1167344-A1 PROCESS FOR PRODUCING 5-AMINO-8- ALKYLQUINOLO NECARBOXYLIC ACID DERIVATIVES AND INTERMEDIATES IN THE PRODUCTION THEREOF DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2002-01-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020193591-A1 Process for producing 5-amino-8-alkylquinolonecarboxylic acid derivative and intermediates in the production thereof SQOR, XDH, SPOUT1 STAT3 2381/4885ADRB2 3720/4885KMT2A 2225/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.