⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7517373 | 0.88 | RNASE1 (0.33) | — | |
| SCHEMBL3577226 | 0.78 | DUT (0.31) | — | |
| SCHEMBL3567690 | 0.77 | P2RY6 (0.35) | — | |
| SCHEMBL7510541 | 0.76 | HPGD (0.33) | — | |
| SCHEMBL1335303 | 0.75 | P2RY6 (0.30) | — | |
| SCHEMBL5223432 | 0.74 | RNASE1 (0.41) | — | |
| SCHEMBL9342027 | 0.73 | SLC28A1 (0.35) | — | |
| SCHEMBL3579745 | 0.72 | DUT (0.45) | — | |
| SCHEMBL8582139 | 0.69 | HPGD (0.31) | — | |
| SCHEMBL6244002 | 0.65 | TK1 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020183502-A1 | Backbone-modified oligonucleotide analogs and methods for using same | MESMAEKER ALAIN DE (CH) | 2002-12-05 | — | — | US | disclosed |
| EP-0586520-B1 | BACKBONE MODIFIED OLIGONUCLEOTIDE ANALOGS | ISIS PHARMACEUTICALS INC (US) | 2000-04-19 | — | — | EP | disclosed |
| US-5602240-A | MODULATE ACTIVITY OF DNA, RNA | CIBA GEIGY AG. (CH) | 1997-02-11 | — | — | US | disclosed |
| EP-0586520-A4 | BACKBONE MODIFIED OLIGONUCLEOTIDE ANALOGS | ISIS PHARMACEUTICALS INC (US) | 1996-01-10 | — | — | EP | disclosed |
| US-5378825-A | Backbone modified oligonucleotide analogs | ISIS PHARMACEUTICALS, INC. (US) | 1995-01-03 | — | — | US | disclosed |
| EP-0586520-A1 | BACKBONE MODIFIED OLIGONUCLEOTIDE ANALOGS | ISIS PHARMACEUTICALS, INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992020823-A1 | BACKBONE MODIFIED OLIGONUCLEOTIDE ANALOGS | ISIS PHARMACEUTICALS, INC. (US) | 1992-11-26 | — | — | WO | disclosed |