Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | PLAAT3 | P53816 | 2/20 | 0.57 |
| ▸ | PLAAT5 | Q96KN8 | 2/20 | 0.57 |
| ▸ | PLAAT2 | Q9NWW9 | 2/20 | 0.57 |
| ▸ | PLAAT4 | Q9UL19 | 2/20 | 0.57 |
| ▸ | MMP12 | P39900 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.51 |
| ▸ | THRA | P10827 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.51 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.51 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7332799 | 0.88 | TAAR1 (0.57) | ALDH1A1KMT2ASMN1; SMN2PLAAT3PLAAT5 | |
| SCHEMBL20897236 | 0.87 | PLAAT3 (0.58) | ALDH1A1KMT2ASMN1; SMN2PLAAT3PLAAT5 | |
| SCHEMBL80581 | 0.86 | ALDH1A1 (0.67) | ALDH1A1KMT2ASMN1; SMN2PLAAT3PLAAT5 | |
| SCHEMBL27834585 | 0.83 | CTBP2 (0.58) | ALDH1A1KMT2ASMN1; SMN2MEN1HPGD | |
| SCHEMBL11064961 | 0.81 | PLAAT3 (0.52) | ALDH1A1KMT2ASMN1; SMN2PLAAT3PLAAT5 | |
| SCHEMBL7507667 | 0.80 | MMP12 (0.54) | ALDH1A1KMT2AMMP12MEN1TAAR1 | |
| SCHEMBL13561129 | 0.80 | PLAAT3 (0.57) | ALDH1A1KMT2ASMN1; SMN2PLAAT3PLAAT5 | |
| SCHEMBL28210558 | 0.80 | FFAR1 (0.57) | ALDH1A1KMT2AMMP12MEN1TAAR1 | |
| SCHEMBL7507038 | 0.80 | MMP12 (0.54) | ALDH1A1MMP12HPGDFFAR1 | |
| SCHEMBL28874674 | 0.80 | PLAAT3 (0.50) | ALDH1A1KMT2ASMN1; SMN2PLAAT3PLAAT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102083827-A | Thiazolidine compounds as orexin receptor antagonists | ACTELION PHARMACEUTICALS LTD | 2011-06-01 | — | — | CN | disclosed |
| EP-1042320-B1 | NEW COMPOUNDS WHICH ARE P2-PURINOCEPTOR 7-TRANSMEMBRANE (TM) G-PROTEIN COUPLED RECEPTOR ANTAGONISTS | ASTRAZENECA UK LTD (GB) | 2002-02-13 | — | — | EP | disclosed |
| US-6218376-B1 | FOR TREATING INFLAMMATORY DISEASES | ASTRAZENECA UK LIMITED (GB) | 2001-04-17 | — | — | US | disclosed |
| EP-1042320-A1 | NEW COMPOUNDS WHICH ARE P2-PURINOCEPTOR 7-TRANSMEMBRANE (TM) G-PROTEIN COUPLED RECEPTOR ANTAGONISTS | AstraZeneca UK Limited (GB) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999026944-A1 | NEW COMPOUNDS WHICH ARE P2-PURINOCEPTOR 7-TRANSMEMBRANE (TM) G-PROTEIN COUPLED RECEPTOR ANTAGONISTS | ASTRAZENEKA UK LIMITED (GB) | 1999-06-03 | — | — | WO | disclosed |
| EP-0068460-A1 | Tricyclic derivatives of substituted pyrrole acids as analgesic and anti-inflammatory agents | MERCK & CO. INC. (US) | 1983-01-05 | — | — | EP | disclosed |