Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.41 |
| ▸ | LGMN | Q99538 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PNP | P00491 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7519640 | 0.88 | MEN1 (0.41) | L3MBTL1MEN1KMT2AADORA2AADORA1 | |
| SCHEMBL18835018 | 0.80 | GFER (0.45) | ALDH1A1MEN1KMT2AADORA2AADORA1 | |
| SCHEMBL10281157 | 0.76 | ALDH1A1 (0.43) | ALDH1A1L3MBTL1KMT2AMAPTPLK1 | |
| SCHEMBL27973711 | 0.73 | MEN1 (0.37) | ALDH1A1L3MBTL1MEN1KMT2AADORA2A | |
| SCHEMBL8656134 | 0.71 | ALDH1A1 (0.47) | ALDH1A1L3MBTL1SMN1; SMN2MAPTPLK1 | |
| SCHEMBL7741672 | 0.68 | PLA2G7 (0.41) | ALDH1A1MEN1KMT2ALGMNSMN1; SMN2 | |
| SCHEMBL4418633 | 0.68 | ALDH1A1 (0.53) | ALDH1A1MEN1KMT2ASMN1; SMN2PNP | |
| SCHEMBL17446077 | 0.67 | NPC1 (0.59) | ALDH1A1L3MBTL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5223001 | 0.67 | KMT2A (0.62) | ALDH1A1MEN1KMT2AADORA2AADORA1 | |
| SCHEMBL12794269 | 0.67 | PDE3B (0.42) | ALDH1A1L3MBTL1KMT2APDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1352637-A | Process for preparing MKC-442 | TRIANGLE PHARMACEUTICALS INC (US) | 2002-06-05 | — | — | CN | disclosed |
| EP-1169310-A1 | PROCESS FOR PREPARING MKC-442 | Triangle Pharmaceuticals Inc. (US) | 2002-01-09 | — | — | EP | disclosed |
| EP-1169310-A1 | PROCESS FOR PREPARING MKC-442 | Triangle Pharmaceuticals Inc. (US) | 2002-01-09 | — | — | EP | disclosed |
| WO-2000061566-A1 | PROCESS FOR PREPARING MKC-442 | TRIANGLE PHARMACEUTICALS, INC. (US) | 2000-10-19 | — | — | WO | disclosed |
| WO-2000061566-A1 | PROCESS FOR PREPARING MKC-442 | TRIANGLE PHARMACEUTICALS, INC. (US) | 2000-10-19 | — | — | WO | disclosed |