Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.41 |
| ▸ | FEN1 | P39748 | 3/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PNP | P00491 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 2/20 | 0.38 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7512202 | 0.88 | ALDH1A1 (0.44) | MEN1KMT2AADORA2AADORA1PDE3B | |
| SCHEMBL20577735 | 0.75 | CASP3 (0.41) | MEN1KMT2ABRD4 | |
| SCHEMBL18835018 | 0.68 | GFER (0.45) | MEN1KMT2AADORA2AADORA1FEN1 | |
| SCHEMBL23163270 | 0.68 | SLC9A1 (0.38) | POLBL3MBTL1 | |
| SCHEMBL5223001 | 0.67 | KMT2A (0.62) | MEN1KMT2AADORA2AADORA1PNP | |
| SCHEMBL13244912 | 0.67 | PDE5A (0.49) | MEN1KMT2AADORA2AADORA1PDE3B | |
| SCHEMBL12794269 | 0.67 | PDE3B (0.42) | KMT2APDE3BPDE3AL3MBTL1CYP1A2 | |
| SCHEMBL22471432 | 0.66 | PGR (0.36) | SMN1; SMN2POLBL3MBTL1 | |
| SCHEMBL24450051 | 0.66 | GAA (0.35) | MEN1KMT2ADAOPOLBL3MBTL1 | |
| SCHEMBL19335113 | 0.66 | HSD17B10 (0.46) | MEN1KMT2ASMN1; SMN2DAOPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107778254-A | The synthetic method of the pyrimidine derivatives of Internmediate of anti viral medicine oxo two | 陈国妃 | 2018-03-09 | — | — | CN | disclosed |
| CN-1352637-A | Process for preparing MKC-442 | TRIANGLE PHARMACEUTICALS INC (US) | 2002-06-05 | — | — | CN | disclosed |
| EP-1169310-A1 | PROCESS FOR PREPARING MKC-442 | Triangle Pharmaceuticals Inc. (US) | 2002-01-09 | — | — | EP | disclosed |
| EP-1169310-A1 | PROCESS FOR PREPARING MKC-442 | Triangle Pharmaceuticals Inc. (US) | 2002-01-09 | — | — | EP | disclosed |
| WO-2000061566-A1 | PROCESS FOR PREPARING MKC-442 | TRIANGLE PHARMACEUTICALS, INC. (US) | 2000-10-19 | — | — | WO | disclosed |
| WO-2000061566-A1 | PROCESS FOR PREPARING MKC-442 | TRIANGLE PHARMACEUTICALS, INC. (US) | 2000-10-19 | — | — | WO | disclosed |