Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 1/20 | 0.45 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.44 |
| ▸ | PLAU | P00749 | 8/20 | 0.44 |
| ▸ | PLG | P00747 | 3/20 | 0.44 |
| ▸ | F10 | P00742 | 3/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | F7 | P08709 | 1/20 | 0.42 |
| ▸ | F3 | P13726 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | PLAT | P00750 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
| ▸ | NNMT | P40261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6120808 | 0.74 | NNMT (0.64) | CTNNB1PLA2G10F10F2KDM4E | |
| SCHEMBL9959804 | 0.71 | MEN1 (0.46) | CTNNB1PLA2G10PLAUPLGF10 | |
| SCHEMBL920637 | 0.70 | PARP10 (0.56) | CTNNB1PLA2G10CYP2C9CYP2C19PARP10 | |
| SCHEMBL28260959 | 0.70 | PARP10 (0.56) | CTNNB1PLA2G10PARP10 | |
| SCHEMBL28059433 | 0.68 | NNMT (0.51) | KDM4EHPGDNNMT | |
| SCHEMBL29193018 | 0.68 | RAB9A (0.51) | CTNNB1PLA2G10F10PARP10 | |
| SCHEMBL14917475 | 0.68 | IKBKB (0.51) | PLAUKDM4EBRD4 | |
| Diphenylether SCHEMBL23068684 | 0.68 | CTNNB1 (0.74) | CTNNB1KDM4EHPGDPARP10 | |
| SCHEMBL28628579 | 0.67 | SMN1; SMN2 (0.62) | KDM4ENNMT | |
| SCHEMBL742272 | 0.67 | RAB9A (0.75) | CTNNB1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2575461-A1 | SUBSTITUTED-6-METHYLNICOTINAMIDES AS MGLUR5 POSITIVE ALLOSTERIC MODULATORS | Vanderbilt University (US) | 2013-04-10 | — | — | EP | disclosed |
| WO-2011149963-A1 | SUBSTITUTED-6-METHYLNICOTINAMIDES AS MGLUR5 POSITIVE ALLOSTERIC MODULATORS | VANDERBILT UNIVERSITY (US) | 2011-12-01 | — | — | WO | disclosed |