Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 6/20 | 0.61 |
| ▸ | REN | P00797 | 8/20 | 0.59 |
| ▸ | CTSS | P25774 | 2/20 | 0.56 |
| ▸ | CTSL | P07711 | 1/20 | 0.56 |
| ▸ | CTSB | P07858 | 1/20 | 0.56 |
| ▸ | CTSK | P43235 | 1/20 | 0.56 |
| ▸ | AKT1 | P31749 | 1/20 | 0.52 |
| ▸ | CCKAR | P32238 | 1/20 | 0.52 |
| ▸ | CCKBR | P32239 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7513191 | 0.85 | CTSL (0.67) | CTSSCTSLCTSBCTSK | |
| SCHEMBL29097057 | 0.82 | CTSK (0.49) | SCN9ARENCTSSCTSLCTSB | |
| SCHEMBL29097060 | 0.82 | CTSK (0.49) | SCN9ARENCTSSCTSLCTSB | |
| SCHEMBL4970302 | 0.82 | CTSK (0.49) | SCN9ARENCTSSCTSLCTSB | |
| SCHEMBL29097056 | 0.82 | CTSK (0.49) | SCN9ARENCTSSCTSLCTSB | |
| SCHEMBL9654466 | 0.81 | SCN9A (0.68) | SCN9ACTSSCTSLCTSBCTSK | |
| SCHEMBL5891488 | 0.81 | SCN9A (0.43) | SCN9AREN | |
| SCHEMBL27424652 | 0.80 | CTSS (0.57) | SCN9ACTSSCTSLCTSBCTSK | |
| SCHEMBL27424651 | 0.80 | CTSS (0.57) | SCN9ACTSSCTSLCTSBCTSK | |
| SCHEMBL7519006 | 0.80 | HDAC3 (0.60) | CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0641800-B1 | Lactol derivatives as inhibitors of cathepsin L | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-01-16 | — | — | EP | disclosed |
| US-5496834-A | PEPTIDE DERIVATIVES AS CATHEPSIN L INHIBITORS AND INHIBITORS OF BONE RESORPTION OR TREATMENT OF OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-03-05 | — | — | US | disclosed |
| US-5480893-A | ANTITUMOR | MERCK & CO., INC. (US) | 1996-01-02 | — | — | US | disclosed |
| EP-0641800-A1 | Lactol derivatives as inhibiters of cathepsin L | Takeda Chemical Industries, Ltd. (JP) | 1995-03-08 | — | — | EP | disclosed |
| US-5340828-A | Anticarcinogenic agents | MERCK & CO., INC. (US) | 1994-08-23 | — | — | US | disclosed |
| EP-0535730-A2 | Inhibitors of farnesyl protein transferase | MERCK & CO. INC. (US) | 1993-04-07 | — | — | EP | disclosed |