Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 11/20 | 0.67 |
| ▸ | CTSK | P43235 | 9/20 | 0.60 |
| ▸ | CTSB | P07858 | 8/20 | 0.60 |
| ▸ | CTSS | P25774 | 4/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7512878 | 0.94 | CTSL (0.65) | CTSLCTSKCTSBCTSS | |
| SCHEMBL4535888 | 0.89 | CTSK (0.76) | CTSLCTSKCTSBCTSS | |
| SCHEMBL7513070 | 0.85 | SCN9A (0.61) | CTSLCTSKCTSBCTSS | |
| SCHEMBL7511180 | 0.84 | MEN1 (0.63) | — | |
| SCHEMBL3169636 | 0.84 | MEN1 (0.63) | — | |
| SCHEMBL6060180 | 0.84 | MEN1 (0.63) | — | |
| SCHEMBL7514927 | 0.83 | CTSK (0.77) | CTSLCTSKCTSBCTSS | |
| SCHEMBL7288696 | 0.81 | MEN1 (0.52) | CTSLCTSKCTSBCTSS | |
| SCHEMBL7451896 | 0.81 | CTSL (1.00) | CTSLCTSKCTSBCTSS | |
| SCHEMBL7448502 | 0.81 | CTSL (1.00) | CTSLCTSKCTSBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0641800-B1 | Lactol derivatives as inhibitors of cathepsin L | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-01-16 | — | — | EP | disclosed |
| US-5496834-A | PEPTIDE DERIVATIVES AS CATHEPSIN L INHIBITORS AND INHIBITORS OF BONE RESORPTION OR TREATMENT OF OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-03-05 | — | — | US | disclosed |
| EP-0641800-A1 | Lactol derivatives as inhibiters of cathepsin L | Takeda Chemical Industries, Ltd. (JP) | 1995-03-08 | — | — | EP | disclosed |