Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 11/20 | 0.62 |
| ▸ | MMP1 | P03956 | 14/20 | 0.59 |
| ▸ | MMP8 | P22894 | 4/20 | 0.53 |
| ▸ | MMP3 | P08254 | 2/20 | 0.53 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydroxyamine SCHEMBL7513406 | 0.87 | ADAM17 (0.78) | ADAM17MMP1MMP8MMP3MMP13 | |
| SCHEMBL27573313 | 0.87 | ADAM17 (0.80) | ADAM17MMP1MMP8MMP3MMP13 | |
| SCHEMBL5758209 | 0.87 | ADAM17 (0.80) | ADAM17MMP1MMP8MMP3MMP13 | |
| SCHEMBL7513418 | 0.81 | ADAM17 (0.76) | ADAM17MMP1MMP8MMP3MMP13 | |
| SCHEMBL5789555 | 0.80 | MMP3 (0.52) | ADAM17MMP1MMP8MMP3MMP13 | |
| SCHEMBL5758134 | 0.80 | MMP1 (0.79) | ADAM17MMP1MMP8MMP3MMP13 | |
| SCHEMBL7214512 | 0.79 | MMP1 (0.83) | ADAM17MMP1MMP8MMP3MMP13 | |
| SCHEMBL7220235 | 0.79 | MMP1 (0.83) | ADAM17MMP1MMP8MMP3MMP13 | |
| SCHEMBL8521431 | 0.78 | ADAM17 (0.62) | ADAM17MMP1MMP8MMP3MMP13 | |
| SCHEMBL7881583 | 0.78 | ADAM17 (0.62) | ADAM17MMP1MMP8MMP3MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1104403-A1 | HYDROXY PIPECOLATE HYDROXAMIC ACID DERIVATIVES AS MMP INHIBITORS | Pfizer Products Inc. (US) | 2001-06-06 | — | — | EP | disclosed |
| WO-2000009485-A1 | HYDROXY PIPECOLATE HYDROXAMIC ACID DERIVATIVES AS MMP INHIBITORS | PFIZER PRODUCTS INC. (US) | 2000-02-24 | — | — | WO | disclosed |