Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 4/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.39 |
| ▸ | FFAR3 | O14843 | 3/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | CTSD | P07339 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.30 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28256993 | 0.80 | HDAC3 (0.40) | HDAC3HDAC1HDAC2HDAC8FFAR3 | |
| SCHEMBL8418815 | 0.78 | FFAR3 (0.44) | HDAC3HDAC1HDAC2HDAC8FFAR3 | |
| SCHEMBL31476971 | 0.75 | AKR1B1 (0.41) | ALDH1A1MEN1KMT2ATSHRFAAH | |
| SCHEMBL6120075 | 0.72 | FAAH (0.55) | CES2CES1ALDH1A1MEN1CYP1A2 | |
| SCHEMBL28986780 | 0.72 | FAAH (0.55) | CES2CES1ALDH1A1MEN1CYP1A2 | |
| SCHEMBL969166 | 0.72 | FAAH (0.55) | CES2CES1ALDH1A1MEN1CYP1A2 | |
| SCHEMBL5745227 | 0.72 | HDAC3 (0.46) | HDAC3HDAC1HDAC2HDAC8FFAR3 | |
| SCHEMBL9346590 | 0.72 | HDAC3 (0.46) | HDAC3HDAC1HDAC2HDAC8FFAR3 | |
| SCHEMBL5270259 | 0.70 | HDAC3 (0.43) | HDAC3HDAC1HDAC2HDAC8FFAR3 | |
| SCHEMBL2776898 | 0.70 | FDPS (0.35) | ALDH1A1MEN1CYP1A2THRBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1073633-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 2001-02-07 | — | — | EP | claimed |
| WO-1999057098-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 1999-11-11 | — | — | WO | claimed |