Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 4/20 | 0.63 |
| ▸ | CTSL | P07711 | 2/20 | 0.63 |
| ▸ | CTSB | P07858 | 2/20 | 0.63 |
| ▸ | CTSS | P25774 | 2/20 | 0.63 |
| ▸ | CAPN1 | P07384 | 14/20 | 0.59 |
| ▸ | CAPNS1 | P04632 | 2/20 | 0.53 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7515061 | 0.87 | CTSK (0.59) | CTSKCTSLCTSBCTSSCAPN1 | |
| SCHEMBL7514607 | 0.87 | CAPN1 (0.49) | CTSKCTSLCTSBCTSSCAPN1 | |
| SCHEMBL7518132 | 0.85 | CAPN1 (0.57) | CTSKCTSLCTSBCTSSCAPN1 | |
| SCHEMBL7516176 | 0.84 | CAPN1 (0.60) | CTSKCTSLCTSBCTSSCAPN1 | |
| SCHEMBL7516164 | 0.84 | CAPN1 (0.60) | CTSKCTSLCTSBCTSSCAPN1 | |
| SCHEMBL8812453 | 0.83 | CASP1 (0.72) | CTSKCAPN1CAPNS1CASP1CASP3 | |
| SCHEMBL8812460 | 0.83 | CASP1 (0.72) | CTSKCAPN1CAPNS1CASP1CASP3 | |
| SCHEMBL7515201 | 0.83 | CAPN1 (0.59) | CTSKCAPN1CAPNS1CASP1CASP3 | |
| SCHEMBL8809577 | 0.82 | CAPN1 (0.71) | CTSKCTSLCTSBCTSSCAPN1 | |
| SCHEMBL8809563 | 0.82 | CAPN1 (0.71) | CTSKCTSLCTSBCTSSCAPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0641800-B1 | Lactol derivatives as inhibitors of cathepsin L | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-01-16 | — | — | EP | claimed |
| US-5496834-A | PEPTIDE DERIVATIVES AS CATHEPSIN L INHIBITORS AND INHIBITORS OF BONE RESORPTION OR TREATMENT OF OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-03-05 | — | — | US | claimed |
| EP-0641800-B1 | Lactol derivatives as inhibitors of cathepsin L | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-01-16 | — | — | EP | disclosed |