Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.61 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.61 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.57 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.54 |
| ▸ | HRH2 | P25021 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | HTR2B | P41595 | 1/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.54 |
| ▸ | LTA4H | P09960 | 5/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30417302 | 1.00 | CHRNB2 (0.61) | CHRNB2CHRNA4CHRNA3CHRNB4SLC6A2 | |
| SCHEMBL7417708 | 1.00 | CHRNB2 (0.61) | CHRNB2CHRNA4CHRNA3CHRNB4SLC6A2 | |
| SCHEMBL7411773 | 0.89 | CHRNA3 (0.54) | CHRNB2CHRNA4CHRNA3CHRNB4SLC6A2 | |
| SCHEMBL3254876 | 0.89 | CHRNA3 (0.54) | CHRNB2CHRNA4CHRNA3CHRNB4SLC6A2 | |
| SCHEMBL14099224 | 0.86 | LTA4H (0.65) | CHRNA3LTA4H | |
| Hydrochloric Acid SCHEMBL4313059 | 0.85 | LTA4H (0.64) | CHRNA3LTA4H | |
| Hydrochloric Acid SCHEMBL4313064 | 0.85 | LTA4H (0.64) | CHRNA3LTA4H | |
| SCHEMBL13809291 | 0.82 | LTA4H (0.71) | LTA4H | |
| SCHEMBL6614963 | 0.81 | POLB (0.45) | CHRNB2CHRNA4LTA4H | |
| Hydrochloric Acid SCHEMBL30181405 | 0.81 | CHRNB2 (0.57) | CHRNB2CHRNA4CHRNA3CHRNB4SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160168111-A1 | FORMATION OF CHIRAL 4-CHROMANONES USING CHIRAL PYRROLIDINES IN THE PRESENCE OF PHENOLS OR THIOPHENOLS | DSM IP ASSETS B.V. (NL) | 2016-06-16 | — | — | US | disclosed |
| US-20160168111-A1 | FORMATION OF CHIRAL 4-CHROMANONES USING CHIRAL PYRROLIDINES IN THE PRESENCE OF PHENOLS OR THIOPHENOLS | DSM IP ASSETS B.V. (NL) | 2016-06-16 | — | — | US | disclosed |
| US-20160073631-A1 | PROCESS FOR THE PREPARATION OF DIHYDROPYRROLE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2016-03-17 | — | — | US | disclosed |
| US-20160073631-A1 | PROCESS FOR THE PREPARATION OF DIHYDROPYRROLE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2016-03-17 | — | — | US | disclosed |
| US-9233920-B2 | Process for the preparation of dihydropyrrole derivatives | SYNGENTA PARTICIPATIONS AG (CH) | 2016-01-12 | — | — | US | disclosed |
| US-9233920-B2 | Process for the preparation of dihydropyrrole derivatives | SYNGENTA PARTICIPATIONS AG (CH) | 2016-01-12 | — | — | US | disclosed |
| EP-2580211-B1 | PROCESS FOR THE PREPARATION OF DIHYDROPYRROLE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2015-08-19 | — | — | EP | disclosed |
| US-20130237583-A1 | PROCESS FOR THE PREPARATION OF DIHYDROPYRROLE DERIVATIVES | SYNGENTA CROP PROTECTION LLC (US) | 2013-09-12 | — | — | US | disclosed |
| US-20130237583-A1 | PROCESS FOR THE PREPARATION OF DIHYDROPYRROLE DERIVATIVES | SYNGENTA CROP PROTECTION LLC (US) | 2013-09-12 | — | — | US | disclosed |
| WO-2011154555-A1 | PROCESS FOR THE PREPARATION OF DIHYDROPYRROLE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2011-12-15 | — | — | WO | disclosed |
| US-20080027035-A1 | Dpp-Iv Inhibitors | GRAFFINITY PHARMACEUTICALS AG (DE) | 2008-01-31 | — | — | US | disclosed |
| US-20080027035-A1 | Dpp-Iv Inhibitors | GRAFFINITY PHARMACEUTICALS AG (DE) | 2008-01-31 | — | — | US | disclosed |
| EP-1613304-B1 | DPP-IV INHIBITORS | SANTHERA PHARMACEUTICALS CH (CH) | 2007-09-12 | — | — | EP | disclosed |
| WO-2005056003-A1 | DPP-IV INHIBITORS | SANTHERA PHARMACEUTICALS (SCHWEIZ) GMBH (CH) | 2005-06-23 | — | — | WO | disclosed |
| EP-1047690-A1 | HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | Abbott Laboratories (US) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999032480-A1 | HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LABORATORIES (US) | 1999-07-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080027035-A1 | Dpp-Iv Inhibitors | DPP4, DPP7, DPP3 | CHRNB2 3365/4885CHRNA4 1167/4885CHRNA3 2401/4885 |
| US-20160168111-A1 | FORMATION OF CHIRAL 4-CHROMANONES USING CHIRAL PYRROLIDINES IN THE PRESENCE OF PHENOLS OR THIOPHENOLS | CYP4B1, CYP4F3, CYP4F2 | CHRNB2 2244/4885CHRNA4 1840/4885CHRNA3 2584/4885 |
| US-20160073631-A1 | PROCESS FOR THE PREPARATION OF DIHYDROPYRROLE DERIVATIVES | CYP1A1, CYP1B1, CYP1A2 | CHRNB2 3089/4885CHRNA4 3436/4885CHRNA3 2884/4885 |
| US-20130237583-A1 | PROCESS FOR THE PREPARATION OF DIHYDROPYRROLE DERIVATIVES | CYP1A1, CYP1B1, CYP1A2 | CHRNB2 3089/4885CHRNA4 3436/4885CHRNA3 2884/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.