Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA3 | P32297 | 2/20 | 0.54 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.54 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.54 |
| ▸ | CHRNG | P07510 | 1/20 | 0.54 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.54 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.54 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.54 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.54 |
| ▸ | CHRND | Q07001 | 1/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3254876 | 1.00 | CHRNA3 (0.54) | CHRNA3CHRNA7CHRNA1CHRNGCHRNB1 | |
| SCHEMBL7417708 | 0.89 | CHRNB2 (0.61) | CHRNA3CHRNB2CHRNB4CHRNA4SLC6A2 | |
| SCHEMBL30417302 | 0.89 | CHRNB2 (0.61) | CHRNA3CHRNB2CHRNB4CHRNA4SLC6A2 | |
| SCHEMBL7515443 | 0.89 | CHRNB2 (0.61) | CHRNA3CHRNB2CHRNB4CHRNA4SLC6A2 | |
| SCHEMBL3358443 | 0.79 | CHRNB2 (0.63) | CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL365267 | 0.78 | GPR39 (0.43) | — | |
| SCHEMBL31192198 | 0.78 | GPR39 (0.43) | — | |
| SCHEMBL10499108 | 0.78 | KDM1A (0.56) | SLC6A2 | |
| SCHEMBL29007944 | 0.77 | CREBBP (0.40) | — | |
| SCHEMBL29007973 | 0.76 | GABRA1 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047690-A1 | HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | Abbott Laboratories (US) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999032480-A1 | HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LABORATORIES (US) | 1999-07-01 | — | — | WO | disclosed |