⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7508801 | 0.76 | CA2 (0.39) | — | |
| SCHEMBL7504951 | 0.75 | GBA1 (0.35) | — | |
| SCHEMBL3577810 | 0.74 | CA2 (0.47) | — | |
| SCHEMBL3585070 | 0.74 | CA2 (0.47) | — | |
| SCHEMBL7508734 | 0.74 | L3MBTL1 (0.38) | — | |
| SCHEMBL9287776 | 0.70 | CA12 (0.36) | — | |
| SCHEMBL4469209 | 0.69 | — | — | |
| SCHEMBL9535803 | 0.68 | KDM4E (0.30) | — | |
| SCHEMBL16385769 | 0.62 | ALDH1A1 (0.52) | — | |
| SCHEMBL8127095 | 0.62 | ALDH1A1 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996010573-A1 | ENANTIOSELECTIVE SYNTHESIS OF SULFONAMIDE INTERMEDIATES | ALCON LABORATORIES, INC. (US) | 1996-04-11 | — | — | WO | claimed |
| US-5470973-A | Synthesis of sulfonamide intermediates | ALCON LABORATORIES, INC. (US) | 1995-11-28 | — | — | US | claimed |
| EP-0527801-B1 | THIOPHENE SULFONAMIDES USEFUL AS CARBONIC ANHYDRASE INHIBITORS | ALCON LAB INC (US) | 2002-07-31 | — | — | EP | disclosed |
| US-5240923-A | Treating glaucoma | ALCON LABORATORIES, INC. (US) | 1993-08-31 | — | — | US | disclosed |