Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.46 |
| ▸ | DHFR | P00374 | 2/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | AKT2 | P31751 | 1/20 | 0.41 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | BCR | P11274 | 1/20 | 0.41 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.40 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.40 |
| ▸ | ITGAL | P20701 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7508846 | 0.87 | RXFP1 (0.44) | DHFRAKT1AKT2AKT3LMNA | |
| SCHEMBL7519963 | 0.87 | CKS1B (0.46) | CNR2LMNASMN1; SMN2RXFP1ALDH1A1 | |
| SCHEMBL7516894 | 0.86 | RXFP1 (0.55) | DHFRAKT1CNR2ITGALLMNA | |
| SCHEMBL7516678 | 0.86 | RXFP1 (0.41) | DHFRAKT1AKT2AKT3RXFP1 | |
| SCHEMBL7519270 | 0.85 | ALDH1A1 (0.42) | LMNASMN1; SMN2HTTRXFP1KMT2A | |
| SCHEMBL7522989 | 0.78 | CNR2 (0.44) | DHFRCNR2KMT2A | |
| SCHEMBL7514338 | 0.77 | RXFP1 (0.45) | AKT1ITGB2ICAM1ITGALLMNA | |
| SCHEMBL7519326 | 0.76 | ALDH1A1 (0.43) | DHFRTRPV1ABL1BCRCNR2 | |
| SCHEMBL7512812 | 0.76 | PTPN11 (0.43) | AKT1TRPV1ABL1BCRCNR2 | |
| SCHEMBL7514586 | 0.75 | ITGAL (0.52) | DHFRABL1BCRCNR2ITGB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165522-A1 | NEUROTROPHIC THIO SUBSTITUTED PYRIMIDINES | Krenitsky Pharmaceuticals, Inc. (US) | 2002-01-02 | — | — | EP | claimed |
| WO-2000059893-A1 | NEUROTROPHIC THIO SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC. (US) | 2000-10-12 | — | — | WO | claimed |