Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | TYR | P14679 | 2/20 | 0.32 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.31 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.31 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.30 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.30 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7526697 | 0.92 | — | — | |
| SCHEMBL7523704 | 0.85 | TYR (0.34) | ALOX5PTGS2TYRCYSLTR2CYSLTR1 | |
| SCHEMBL7522339 | 0.85 | GABRA1 (0.35) | — | |
| SCHEMBL8443601 | 0.81 | BID (0.36) | PTGS2TYR | |
| SCHEMBL7526911 | 0.80 | GABRA1 (0.39) | — | |
| SCHEMBL7521517 | 0.77 | ALOX15 (0.34) | TYR | |
| SCHEMBL7515184 | 0.74 | TYR (0.38) | ALOX5TYRCYSLTR2CYSLTR1 | |
| SCHEMBL7520240 | 0.73 | GABRA1 (0.38) | — | |
| SCHEMBL7519331 | 0.73 | NPSR1 (0.32) | TYR | |
| SCHEMBL7520622 | 0.72 | FAAH (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900225-B1 | ALKYL-4-SILYL-PHENOLS AND ESTERS THEREOF AS ANTIATHEROSCLEROTIC AGENTS | AVENTIS PHARMA INC (US) | 2002-01-30 | — | — | EP | disclosed |
| US-5608095-A | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents | HOECHST MARION ROUSSEL, INC. (US) | 1997-03-04 | — | — | US | disclosed |