Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | IDO1 | P14902 | 2/20 | 0.49 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.46 |
| ▸ | CDK2 | P24941 | 3/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | SCD | O00767 | 1/20 | 0.46 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.45 |
| ▸ | ACP1 | P24666 | 1/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5840422 | 0.81 | KDR (0.72) | KDRGSTO1CCNE1CDK2CDK5 | |
| SCHEMBL30142626 | 0.72 | KDR (0.65) | KDRGSTO1KDM4ECCNE1CDK2 | |
| SCHEMBL24074022 | 0.72 | KDR (0.65) | KDRGSTO1KDM4ECCNE1CDK2 | |
| SCHEMBL17632040 | 0.68 | ABL1 (0.62) | KDRGSTO1CCNE1CDK2CDK5 | |
| SCHEMBL17014785 | 0.68 | KDR (0.68) | KDRGSTO1MAPTCCNE1CDK2 | |
| SCHEMBL2256136 | 0.67 | KDR (0.72) | KDRGSTO1CCNE1CDK2CDK5 | |
| SCHEMBL10252594 | 0.67 | KDR (1.00) | KDRGSTO1MAPTCCNE1CDK2 | |
| SCHEMBL24278323 | 0.67 | IDO1 (0.53) | IDO1KDM4EMAPTCYP3A4ALDH1A1 | |
| SCHEMBL224770 | 0.67 | KDM4E (1.00) | IDO1KDM4EMAPTCYP3A4ALDH1A1 | |
| SCHEMBL15086878 | 0.66 | ALOX5 (0.74) | GSTO1KDM4EMAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020165259-A1 | Carbon substituted aminothiazole inhibitors of cyclin dependent kinases | RAWLINS DAVID B (US) | 2002-11-07 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020165259-A1 | Carbon substituted aminothiazole inhibitors of cyclin dependent kinases | CCNK, CDK2, CCNL2 | KDR 857/4885IDO1 2331/4885GSTO1 1702/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.