SCHEMBL7518302

SCHEMBL7518302

[CH2]c1ccccc1CN1C(=O)c2ccccc2C1=O

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CASP3 P42574 3/20 0.49
KMT2A Q03164 3/20 0.47
ALDH1A1 P00352 2/20 0.47
PKM P14618 2/20 0.47
MEN1 O00255 2/20 0.47
GAA P10253 2/20 0.45
KDM4E B2RXH2 1/20 0.45
RECQL P46063 1/20 0.45
GRM5 P41594 1/20 0.44
CA12 O43570 2/20 0.44
CA9 Q16790 2/20 0.44
GLS O94925 1/20 0.44
TSHR P16473 2/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
RXFP1 Q9HBX9 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2C19 P33261 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11413584 0.77 CLTC (0.54) CASP3KMT2AALDH1A1PKMMEN1
SCHEMBL3213661 0.77 CASP3 (0.49) CASP3KMT2AALDH1A1PKMMEN1
SCHEMBL5697024 0.77 MAPT (0.54) CASP3KMT2AALDH1A1PKMMEN1
SCHEMBL15624560 0.77 MPO (0.50) CASP3KMT2AALDH1A1PKMMEN1
SCHEMBL10304923 0.77 PTGS1 (0.65) CASP3KMT2AMEN1GAAKDM4E
SCHEMBL7987177 0.77 CASP3 (0.49) CASP3KMT2AALDH1A1PKMMEN1
SCHEMBL6095022 0.77 TYR (0.64) CASP3KMT2AALDH1A1PKMMEN1
SCHEMBL10339317 0.77 TYR (0.64) CASP3KMT2AALDH1A1MEN1GAA
SCHEMBL17866115 0.77 CASP3 (0.53) CASP3KMT2AALDH1A1PKMMEN1
SCHEMBL29819864 0.77 ACHE (0.57) CASP3ALDH1A1CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1179529-A1 NOVEL HYDROXAMIC ACID DERIVATIVES Daiichi Fine Chemical Co., Ltd. (JP) 2002-02-13 EP claimed
EP-1038864-A1 NOVEL METALLOPROTEINASE INHIBITORS FUJI YAKUHIN KOGYO KABUSHIKI KAISHA (JP) 2000-09-27 EP claimed
EP-1179529-A1 NOVEL HYDROXAMIC ACID DERIVATIVES Daiichi Fine Chemical Co., Ltd. (JP) 2002-02-13 EP disclosed
EP-1101492-A1 NOVEL REMEDIES FOR ALLERGIC DISEASES FUJI YAKUHIN KOGYO KABUSHIKI KAISHA (JP) 2001-05-23 EP disclosed
EP-1038864-A1 NOVEL METALLOPROTEINASE INHIBITORS FUJI YAKUHIN KOGYO KABUSHIKI KAISHA (JP) 2000-09-27 EP disclosed