Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX4 | Q99571 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.35 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4742835 | 0.76 | LMNA (0.47) | P2RX4MAPTSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL1966470 | 0.76 | SMN1; SMN2 (0.46) | MAPTSMN1; SMN2ALDH1A1LMNAGAA | |
| Biphenyl SCHEMBL7062651 | 0.73 | ALDH1A1 (0.60) | PTPN1GSK3BMAPTSMN1; SMN2ALDH1A1 | |
| Biphenyl SCHEMBL3399859 | 0.73 | ALDH1A1 (0.60) | PTPN1GSK3BMAPTSMN1; SMN2ALDH1A1 | |
| Biphenyl SCHEMBL5071211 | 0.73 | ALDH1A1 (0.60) | PTPN1GSK3BMAPTSMN1; SMN2ALDH1A1 | |
| Biphenyl SCHEMBL27755857 | 0.69 | ALDH1A1 (0.75) | MAPTSMN1; SMN2ALDH1A1NPC1RAB9A | |
| Biphenyl SCHEMBL310004 | 0.69 | ALDH1A1 (0.53) | MAPTSMN1; SMN2ALDH1A1LMNATSHR | |
| Biphenyl SCHEMBL27930698 | 0.69 | ALDH1A1 (0.53) | PTPN1GSK3BMAPTSMN1; SMN2ALDH1A1 | |
| Biphenyl SCHEMBL2901532 | 0.69 | SMN1; SMN2 (0.61) | MAPTSMN1; SMN2ALDH1A1LMNATSHR | |
| SCHEMBL9592299 | 0.67 | CA12 (0.47) | P2RX4MAPTALDH1A1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0698602-B1 | Process for the preparation of 5-chlorocarbonyl-5H-dibenz(b,f)azepine | AWD PHARMA GMBH & CO KG (DE) | 2002-02-06 | — | — | EP | disclosed |
| EP-0698602-A1 | Process for the preparation of 5-chlorocarbonyl-5H-dibenz(b,f)azepine | ARZNEIMITTELWERK DRESDEN GMBH (DE) | 1996-02-28 | — | — | EP | disclosed |
| US-5185443-A | Method for preparing 5-carbamoyl-5H-dibenz[b,f]azepine | ARZNEIMITTELWERK DRESDEN GMBH (DE) | 1993-02-09 | — | — | US | disclosed |
| US-5110923-A | METHOD FOR PREPARING 5-CHLOROCARBONYL-5H-DIBENZ(B,F)AZEPINE | ARZNEIMITTELWERK DRESDEN GMBH (DE) | 1992-05-05 | — | — | US | disclosed |
| EP-0466972-A1 | Process for the preparation of 5-chlorocarbonyl-5H-dibenzo-[b,f]azepine | ARZNEIMITTELWERK DRESDEN GmbH (DE) | 1992-01-22 | — | — | EP | disclosed |