Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | POLQ | O75417 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30626928 | 0.81 | HSD11B1 (0.42) | IDO1HSD11B1ALDH1A1NOTUMCYP1A2 | |
| SCHEMBL2295972 | 0.81 | HSD11B1 (0.42) | IDO1HSD11B1ALDH1A1NOTUMCYP1A2 | |
| SCHEMBL9563607 | 0.78 | HSD11B1 (0.33) | IDO1HSD11B1NOTUMNR1H2NR1H3 | |
| SCHEMBL1052795 | 0.77 | HSD11B1 (0.42) | IDO1HSD11B1ALDH1A1NOTUMCYP1A2 | |
| SCHEMBL29913869 | 0.73 | ALDH1A1 (0.39) | IDO1HSD11B1ALDH1A1NOTUMCYP1A2 | |
| SCHEMBL8983836 | 0.71 | TSHR (0.39) | ALDH1A1CYP3A4TDP1TSHRHSD17B10 | |
| Bromide SCHEMBL19405537 | 0.71 | HSD11B1 (0.38) | IDO1HSD11B1ALDH1A1NOTUMCYP1A2 | |
| Bromide SCHEMBL19405666 | 0.71 | HSD11B1 (0.42) | HSD11B1ALDH1A1NOTUMCYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL19405387 | 0.71 | HSD11B1 (0.42) | HSD11B1ALDH1A1NOTUMCYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL19405518 | 0.71 | HSD11B1 (0.38) | HSD11B1ALDH1A1NOTUMCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900225-B1 | ALKYL-4-SILYL-PHENOLS AND ESTERS THEREOF AS ANTIATHEROSCLEROTIC AGENTS | AVENTIS PHARMA INC (US) | 2002-01-30 | — | — | EP | disclosed |
| US-5608095-A | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents | HOECHST MARION ROUSSEL, INC. (US) | 1997-03-04 | — | — | US | disclosed |
| EP-0710241-A1 | NOVEL SILYLATED BENZYLAMINE DERIVATIVES, SALTS THEREOF, METHODS OF MANUFACTURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PIERRE FABRE MEDICAMENT (FR) | 1996-05-08 | — | — | EP | disclosed |
| WO-1995003313-A1 | NOVEL SILYLATED BENZYLAMINE DERIVATIVES, SALTS THEREOF, METHODS OF MANUFACTURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PIERRE FABRE MEDICAMENT (FR) | 1995-02-02 | — | — | WO | disclosed |