SCHEMBL751995

SCHEMBL751995

N=Nc1cccc2nnn(O)c12

nearest known ligand 0.45

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.45
POLB P06746 1/20 0.44
MAPK1 P28482 1/20 0.44
ATM Q13315 1/20 0.44
LMNA P02545 1/20 0.37
MAPT P10636 1/20 0.37
DGAT1 O75907 1/20 0.33
PKM P14618 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28388008 0.78 KDM4E (0.41) KDM4EPOLBMAPK1ATMLMNA
SCHEMBL3282387 0.72 KDM4E (0.49) KDM4EPOLBMAPK1ATMLMNA
SCHEMBL28390322 0.72 KDM4E (0.49) KDM4EPOLBMAPK1ATMLMNA
SCHEMBL13730894 0.72 KDM4E (0.49) KDM4EPOLBMAPK1ATMLMNA
SCHEMBL19664183 0.68
SCHEMBL6274820 0.68 KDM4E (0.45) KDM4EPOLBMAPK1ATMLMNA
SCHEMBL27552170 0.68 KDM4E (0.49) KDM4EPOLBMAPK1ATMLMNA
SCHEMBL5921930 0.68 KDM4E (0.45) KDM4EPOLBMAPK1ATMLMNA
SCHEMBL5921928 0.67 KDM4E (0.44) KDM4EPOLBMAPK1ATMLMNA
SCHEMBL31464931 0.66 FGFR1 (0.47) KDM4EPOLBMAPK1ATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1102 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118240281-A Graphite-phase carbon nitride-based antioxidant and preparation method and application thereof 福州大学 2024-06-25 CN claimed
CN-114920790-B Synthesis method of oligonucleotide-diimide compound 康龙化成(宁波)科技发展有限公司 2024-06-14 CN claimed
CN-116218270-B Dual-response anticorrosive filler and preparation method and application thereof 中海油常州涂料化工研究院有限公司 2024-06-07 CN claimed
EP-3702354-B1 COMPOUND HAVING ERK KINASE INHIBITORY ACTIVITY AND USE THEREOF HAIHE BIOPHARMA CO LTD (CN) 2024-05-22 EP claimed
CN-108148044-B Amide compound and method for preparing Vonoprazan fumarate from same 上海医药工业研究院 2024-05-14 CN claimed
CN-117820613-A Preparation method and application of 2, 5-furandicarboxylic acid polyester synthesized by solution method 中国科学院大连化学物理研究所 2024-04-05 CN claimed
CN-112851664-B Pyrazolo [1,5-a ] pyridine-3-nitrile compound and application thereof in medicine 浙江海正药业股份有限公司 2024-03-29 CN claimed
US-20240033368-A1 PREPARATION AND PURIFICATION METHOD OF ANTIBODY DRUG CONJUGATE INTERMEDIATE REMEGEN CO., LTD. (CN) 2024-02-01 US claimed
CN-117448983-A Flame-retardant and antistatic polyester fiber and preparation method thereof 安徽大学 2024-01-26 CN claimed
CN-117338900-A External gel preparation for promoting diabetic wound healing and preparation method and application thereof 中国药科大学 2024-01-05 CN claimed
CN-101691399-A Method for solid phase synthesis of bitter gourd MC-JJ6221 peptide analogs under microwave irradiation and application of bitter gourd MC-JJ6221 peptide analogs UNIV CHINA PHARMA 2010-04-07 CN claimed
CN-101685274-A Cleaning agent for thick-film photoresist ANJI MICROELECTRONICS CO LTD 2010-03-31 CN claimed
CN-101674835-A Process for preparing galanthamine SCINOPHARM TAIWAN LTD 2010-03-17 CN claimed
CN-101665529-A Method for promoting solid phase synthesis of balsam pear MC-JJ22 polypeptide analogue by microwaves and application thereof UNIV CHINA PHARMA 2010-03-10 CN claimed
CN-101665528-A Method for promoting solid phase synthesis of balsam pear MC-JJ2 polypeptide analogue by microwaves and application thereof UNIV CHINA PHARMA 2010-03-10 CN claimed
CN-101613386-A Gambogic acid cyclized analog and its production and application LIAONING LIFENG SCIENCE AND TE 2009-12-30 CN claimed
CN-101289482-A Cambogic acid glycoside derivates and the like, preparation and uses thereof LIAONING LIFENG TECHNOLOGY AND (CN) 2008-10-22 CN claimed
CN-101274935-A Amino acid-containing palisade porphyrin compound, preparation thereof and application thereof INST BIOMEDICAL ENG CAMS (CN) 2008-10-01 CN claimed
CN-101274958-A Bioactive peptide, preparation thereof and application thereof OCEAN UNIV CHINA (CN) 2008-10-01 CN claimed
CN-101255191-A Micro-wave promoted solid-phase synthesis of glucagons-like peptide-1(GLP-1) analogue and uses thereof UNIV CHINA PHARMA (CN) 2008-09-03 CN claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240033368-A1 PREPARATION AND PURIFICATION METHOD OF ANTIBODY DRUG CONJUGATE INTERMEDIATE FCGR2A, FCGR3B, FCGR1A KDM4E 1685/4885POLB 741/4885MAPK1 3318/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.