SCHEMBL7520741

SCHEMBL7520741

C=CCc1c(O)cc(C(C)(C)C)c(OC(C)=O)c1C(C)(C)C

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.39
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
PTGS1 P23219 1/20 0.36
SRD5A1 P18405 1/20 0.36
VCAM1 P19320 9/20 0.33
ALOX5 P09917 2/20 0.33
MAPT P10636 2/20 0.33
ALDH1A1 P00352 1/20 0.33
CYP1A2 P05177 1/20 0.33
ALOX15 P16050 1/20 0.33
ATP2A2 P16615 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
ATP2A3 Q93084 1/20 0.33
ELANE P08246 1/20 0.32
TP53 P04637 1/20 0.31
GAA P10253 1/20 0.31
HTT P42858 1/20 0.31
HSD17B10 Q99714 1/20 0.31
KDR P35968 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9026764 0.87 KDM4E (0.39) KDM4EMEN1KMT2APTGS1SRD5A1
SCHEMBL8369415 0.85 PTGS1 (0.46) KDM4EMEN1KMT2APTGS1SRD5A1
SCHEMBL7524587 0.83 VCAM1 (0.33) KDM4EVCAM1MAPTALDH1A1CYP1A2
SCHEMBL7523149 0.82 KDM4E (0.35) KDM4EVCAM1MAPTALDH1A1CYP1A2
SCHEMBL8368606 0.81 SLC5A1 (0.33) KDM4EPTGS1VCAM1MAPTALDH1A1
SCHEMBL8863932 0.80 ALOX15 (0.33) KDM4EPTGS1ALOX5MAPTALDH1A1
SCHEMBL7519825 0.79 KDM4E (0.34) KDM4EMEN1KMT2APTGS1SRD5A1
SCHEMBL8690464 0.79 KDM4E (0.34) KDM4EMEN1KMT2APTGS1SRD5A1
SCHEMBL8691188 0.78 KDM4E (0.34) KDM4EMEN1KMT2APTGS1SRD5A1
SCHEMBL8864686 0.77 SRD5A1 (0.40) KDM4EMEN1KMT2APTGS1SRD5A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0791589-B1 4,6-DI-t-BUTYL-2,3-DIHYDROBENZOTHIOPHENES WHICH INHIBIT LDL OXIDATION CHUGAI PHARMACEUTICAL CO LTD (JP) 2002-03-06 EP disclosed
CN-1073563-C 4, 6-di-tert-butyl-2, 3-dihydrobenzothiophene derivatives CHUGAI PHARMACEUTICAL CO LTD (JP) 2001-10-24 CN disclosed
CN-1054128-C 4-alkoxy-2,6-ditert-butyphynol derivative CHUGAI PHARMACEUTICAL CO LTD (JP) 2000-07-05 CN disclosed
EP-0665208-B1 4-ALKOXY-2,6-DI-t-BUTYLPHENOL DERIVATIVE CHUGAI PHARMACEUTICAL CO LTD (JP) 1999-01-13 EP disclosed
US-5789436-A ARTERIOSCLEROSIS; INHIBITORS OF OXIDATION OF LOW DENSITY LIPOPROTEINS; CHUGAI SEIYAK KABUSHIKI KAISHA (JP) 1998-08-04 US disclosed
US-5663373-A ANTIISCHEMIC AGENTS AND ANTIOXIDANTS FORMED IN MULTISTAGE REACTION WITH GRIGNARD REAGENT WITH ALDEHYDE, DISSOLVING, ACIDIFICATION, DEPROTECTION AND CYCLIZATION CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 1997-09-02 US disclosed
EP-0791589-A1 4,6-DI-t-BUTYL-2,3-DIHYDROBENZOTHIOPHENES WHICH INHIBIT LDL OXIDATION CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 1997-08-27 EP disclosed
CN-1148386-A 4,6-di-5-butyl-2,3-dihydrobenzothiophene derivative CHUGAI PHARMACEUTICAL CO LTD (JP) 1997-04-23 CN disclosed
US-5606089-A ANTIISCHEMIC AGENTS CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 1997-02-25 US disclosed
US-5574178-A CHEMICAL INTERMEDIATES FOR OXIDATION RESISTANCE AND ANTIISCHEMIC AGENTS FORMED BY MULTISTAGE CYCLIZATION OF ALDEHYDE-ALCOHOL CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 1996-11-12 US disclosed
CN-1112115-A 4-alkoxy-2, 6-di-tert-butylphenol derivative CHUGAI PHARMACEUTICAL CO LTD (JP) 1995-11-22 CN disclosed
EP-0665208-A1 4-ALKOXY-2,6-DI-t-BUTYLPHENOL DERIVATIVE Chugai Seiyaku Kabushiki Kaisha (JP) 1995-08-02 EP disclosed