SCHEMBL7523149

SCHEMBL7523149

CC(=O)Oc1c(C(C)(C)C)cc(O)c(CN)c1C(C)(C)C

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.35
MAPT P10636 2/20 0.35
ALOX15 P16050 2/20 0.35
ALDH1A1 P00352 1/20 0.35
CYP1A2 P05177 1/20 0.35
ATP2A2 P16615 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
ATP2A3 Q93084 1/20 0.35
VCAM1 P19320 10/20 0.35
TP53 P04637 2/20 0.33
GAA P10253 1/20 0.33
HTT P42858 1/20 0.33
HSD17B10 Q99714 1/20 0.33
NR1H4 Q96RI1 1/20 0.32
KDR P35968 1/20 0.32
PREP P48147 1/20 0.32
CELA1 Q9UNI1 1/20 0.32
CA2 P00918 1/20 0.32
CYP3A4 P08684 2/20 0.32
LMNA P02545 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7524587 0.83 VCAM1 (0.33) KDM4EMAPTALOX15ALDH1A1CYP1A2
SCHEMBL7520741 0.82 KDM4E (0.39) KDM4EMAPTALOX15ALDH1A1CYP1A2
SCHEMBL6307528 0.81 MAPT (0.36) KDM4EMAPTALOX15ALDH1A1CYP1A2
SCHEMBL7526384 0.79 ALDH1A1 (0.34) KDM4EMAPTALOX15ALDH1A1CYP1A2
SCHEMBL8368654 0.79 KDM4E (0.40) KDM4EMAPTALOX15ALDH1A1CYP1A2
SCHEMBL8367229 0.79 VCAM1 (0.34) KDM4EMAPTALOX15ALDH1A1CYP1A2
SCHEMBL7526381 0.75 NR1H4 (0.34) KDM4EMAPTALOX15ALDH1A1CYP1A2
SCHEMBL7526354 0.74 ALOX5 (0.34) VCAM1GAA
SCHEMBL8368606 0.73 SLC5A1 (0.33) KDM4EMAPTALOX15ALDH1A1CYP1A2
SCHEMBL27373776 0.73 VCAM1 (0.33) VCAM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0791589-B1 4,6-DI-t-BUTYL-2,3-DIHYDROBENZOTHIOPHENES WHICH INHIBIT LDL OXIDATION CHUGAI PHARMACEUTICAL CO LTD (JP) 2002-03-06 EP disclosed
CN-1073563-C 4, 6-di-tert-butyl-2, 3-dihydrobenzothiophene derivatives CHUGAI PHARMACEUTICAL CO LTD (JP) 2001-10-24 CN disclosed
EP-0665208-B1 4-ALKOXY-2,6-DI-t-BUTYLPHENOL DERIVATIVE CHUGAI PHARMACEUTICAL CO LTD (JP) 1999-01-13 EP disclosed
US-5789436-A ARTERIOSCLEROSIS; INHIBITORS OF OXIDATION OF LOW DENSITY LIPOPROTEINS; CHUGAI SEIYAK KABUSHIKI KAISHA (JP) 1998-08-04 US disclosed
US-5663373-A ANTIISCHEMIC AGENTS AND ANTIOXIDANTS FORMED IN MULTISTAGE REACTION WITH GRIGNARD REAGENT WITH ALDEHYDE, DISSOLVING, ACIDIFICATION, DEPROTECTION AND CYCLIZATION CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 1997-09-02 US disclosed
EP-0791589-A1 4,6-DI-t-BUTYL-2,3-DIHYDROBENZOTHIOPHENES WHICH INHIBIT LDL OXIDATION CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 1997-08-27 EP disclosed
CN-1148386-A 4,6-di-5-butyl-2,3-dihydrobenzothiophene derivative CHUGAI PHARMACEUTICAL CO LTD (JP) 1997-04-23 CN disclosed
US-5606089-A ANTIISCHEMIC AGENTS CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 1997-02-25 US disclosed
US-5574178-A CHEMICAL INTERMEDIATES FOR OXIDATION RESISTANCE AND ANTIISCHEMIC AGENTS FORMED BY MULTISTAGE CYCLIZATION OF ALDEHYDE-ALCOHOL CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 1996-11-12 US disclosed
EP-0665208-A1 4-ALKOXY-2,6-DI-t-BUTYLPHENOL DERIVATIVE Chugai Seiyaku Kabushiki Kaisha (JP) 1995-08-02 EP disclosed